Results 21 to 30 of about 1,312,751 (242)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
CGIAR GENDER Impact Platform Newsletter, issue 2, June-July 2022
In this issue, we share with you latest news from the CGIAR GENDER Impact Platform as well as updates on gender research from across CGIAR's research portfolio.
CGIAR GENDER Impact Platform
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We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
CGIAR Excellence in Breeding Platform - Plan of Work and Budget 2018 [PDF]
CGIAR Excellence in Breeding Platform - Plan of Work and Budget for ...
CGIAR Excellence in Breeding Platform
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Biophysical approaches for studying viral entry
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
CGIAR GENDER Platform - Plan of Work and Budget 2020
Being the first year of the Platform, no changes are envisioned of the Theory of Change as outlined in the proposal. Specific activities, such as the Resource and Learning Hubs, identified from the ENGAGE proposal (led by IFPRI) will be integrated into ...
CGIAR GENDER Platform
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CGIAR GENDER Platform Research Agenda: Summary notes of virtual workshop on July 13, 14 & 16, 2020.
The GENDER Platform team organized this virtual workshop to move forward the Platform’s research agenda. The workshop was designed to assess and create a shared view of the current state of the gender research portfolio within the Platform and across the
CGIAR GENDER Platform
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