Updated knowledge and a proposed nomenclature for nuclear receptors with two DNA binding domains (2DBD-NRs). [PDF]
PLoS ONE, 2023 Nuclear receptors (NRs) are important transcriptional modulators in metazoans. Typical NRs possess a conserved DNA binding domain (DBD) and a ligand binding domain (LBD).
Wenjie Wu, Philip T LoVerde
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Correction: Identification and evolution of nuclear receptors in Platyhelminths. [PDF]
PLoS ONE[This corrects the article DOI: 10.1371/journal.pone.0250750.].
Wenjie Wu, Philip T LoVerde
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Convergent evolution of the sensory pits in and within flatworms [PDF]
BMC Biology, 2023 Background Unlike most free-living platyhelminths, catenulids, the sister group to all remaining flatworms, do not have eyes. Instead, the most prominent sensory structures in their heads are statocysts or sensory pits.
Ludwik Gąsiorowski +6 more
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Identification and evolution of nuclear receptors in Platyhelminths. [PDF]
PLoS ONE, 2021 Since the first complete set of Platyhelminth nuclear receptors (NRs) from Schistosoma mansoni were identified a decade ago, more flatworm genome data is available to identify their NR complement and to analyze the evolutionary relationship of ...
Wenjie Wu, Philip T LoVerde
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Sensitive and accurate DNA metabarcoding of parasitic helminth mock communities using the mitochondrial rRNA genes [PDF]
Scientific Reports, 2022 Next-generation sequencing technologies have accelerated the pace of helminth DNA metabarcoding research, enabling species detection in bulk community samples.
Abigail Hui En Chan +7 more
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Widespread gene fusion artifacts in helminth genome annotations [PDF]
BMC GenomicsBackground Current helminth genomes possess thousands of predicted fusion genes, encoding novel protein domain architectures that are unique to these species.
Emma L. Collington +3 more
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Screening Novel Furoxan Derivatives as Potential Inhibitors Targeting Thioredoxin Glutathione Reductase of Fasciola gigantica [PDF]
PharmaceuticalsBackground: Fascioliasis, caused by Fasciola species, is a significant public health concern affecting over 250 million people globally and causing annual economic losses exceeding USD 6 billion.
Yanhui Han +12 more
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The DEAD-box RNA helicase eIF4A is a crucial factor for stem-cell activity and reproduction of the parasite Schistosoma mansoni [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionThe parasite Schistosoma mansoni has a unique reproductive biology, because female maturation depends on constant pairing with a male. Paired females produce each up to 300 eggs per day, which are the pathogenic factors of schistosomiasis, a ...
Sophie Welsch +6 more
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Identifying potential drug targets in the kinomes of two monogenean species [PDF]
HelminthologiaProtein kinases are enzymes involved in essential biological processes such as signal transduction, transcription, metabolism, and the cell cycle. Human kinases are targets for several drugs approved by the US Food and Drug Administration. Therefore, the
Caña-Bozada V. H. +4 more
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Where traditional extinction estimates fall flat: using novel cophylogenetic methods to estimate extinction risk in platyhelminths [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2022 Laura P A Mulvey +2 more
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