Results 61 to 70 of about 169 (167)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Furosemide‐hydration matching with RenalGuard® in decompensated heart failure: an alternative way to use diuretics and saline

ESC Heart Failure, EarlyView.
Massimo Mapelli, Filippo Maria Rubbo, Jeness Campodonico, Nicola Cosentino, Giancarlo Marenzi, Valentina Mantegazza, Filippo Trombara, Mateusz Sokolski, Piotr Ponikowski, Piergiuseppe Agostoni   +9 more
wiley   +1 more source

Histologically verified penile lichen sclerosus—Incidence in Denmark over 26 years and long‐term risk of penile and non‐penile cancer

International Journal of Cancer, EarlyView.
What's New? About half of penile squamous cell carcinomas are causally associated with inflammatory conditions such as lichen sclerosus (LSc), but few large‐scale studies have assessed the risk of penile cancer in men with LSc. Here, the authors conducted a large nationwide study in Denmark to estimate the risk of penile and non‐penile cancer in men ...
Marianne Gardar Stærk, Emma L. Kaderly Rasmussen, Charlotte Gerd Hannibal, Rasmus Hertzum‐Larsen, Louise Baandrup, Susanne K. Kjær   +5 more
wiley   +1 more source

Mass cytometric detection of homologous recombination proficiency in circulating tumor cells to predict chemoresistance of metastatic breast cancer patients

International Journal of Cancer, EarlyView.
What's New? Circulating tumor cells can offer insights into treatment responses and metastatic recurrence, but current analysis methods are limited. Here, the authors tested a newly developed mass cytometry panel comprising biomarkers such as γH2AX and RAD51 in longitudinally monitored metastatic breast cancer patients.
Kathrin Niedermayer, Henning Schäffler, Georgios Vlachos, Sara Greco, Kerstin Pfister, Barbara Volz, Leonie Ott, Hans Neubauer, Bernhard Polzer, André Koch, Sabine Riethdorf, Tanja Fehm, Wolfgang Janni, Thomas W. P. Friedl, Brigitte Rack, Ellen Heitzer, Fabienne Schochter, Lisa Wiesmüller   +17 more
wiley   +1 more source

Worldwide barriers of optimal surgical care provision in advanced ovarian cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Ovarian cancer (OC) remains one of the most challenging gynecological malignancies to cure, despite recent advances in treatment. Disparities in the diagnosis, management, and survival of OC exist worldwide and addressing them remains an ongoing challenge.
Shriya Varghese, Myong Cheol Lim, Robert Armbrust, Rene Pareja, Christina Fotopoulou   +4 more
wiley   +1 more source

Ultrasound‐guided intercostal block for the management of intercostal neuralgia in pregnant women: Case series and review of the literature

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Intercostal neuralgia (ICN) in pregnancy is a rare condition which, to date, has not been well studied. Due to the lack of evidence, there is not a consensus about effective therapeutic strategies for this condition. The present study investigated the feasibility of ultrasound‐guided intercostal block (UG‐ICB) using ropivacaine for these ...
Laura Tascón Padrón, Norah L. A. Emrich, Carolin Schröder, Florian Recker, Brigitte Strizek, Jorge Jiménez Cruz   +5 more
wiley   +1 more source

Rare Infectious Diseases: Detection and Clinical Implications

iLABMED, EarlyView.
Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian, Yuxin Zhang, Yilin Ye, Qiange Lin, Junyou Lin, Xinrong Lu, Li Chen, Guiqin Sun   +7 more
wiley   +1 more source

Organoid‐tissue extracellular vesicles

Interdisciplinary Medicine, EarlyView.
Abstract Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment.
Han Liu, Ting Cheng, Guangfeng Li, Zhidao Xia, Chenglong Wang, Ke Xu, Jiacan Su   +6 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Integrating surface‐enhanced Raman scattering with machine learning: Pioneering a comprehensive diagnostic and therapeutic platform for cancer management

Interdisciplinary Medicine, EarlyView.
Integrating Surface‐Enhanced Raman Scattering (SERS) with machine learning creates a powerful platform for cancer management. This approach enhances diagnostic precision through non‐invasive molecular fingerprinting and enables real‐time therapeutic monitoring. By combining SERS with machine learning, it offers a comprehensive solution for early cancer
Heng‐Zhou He, La Zhang, Yi‐Lin Wen, Yan‐Yang Wang, Jun‐Yan Zhang, Fei‐Hao Yao, Ji‐Yao Yu, Jing‐Xian Wu, Qi‐Ling Peng, Ning Jiang   +9 more
wiley   +1 more source