Results 311 to 320 of about 353,133 (388)

Glymphatic System May Mediate the Relation Between Choroid Plexus and Brain Damage in Multiple Sclerosis. [PDF]

Neurol Neuroimmunol Neuroinflamm
Preziosa P, Pagani E, Margoni M, Rubin M, Storelli L, Corazzolla G, Rocca MA, Filippi M.   +7 more
europepmc   +1 more source

Paediatric Varicocele Embolisation: Clinical Experience, Insights and Long Term Clinical Outcomes Over 14 Years at a Tertiary Centre—A Cohort Study

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Varicocele is a correctable cause of male infertility with management options including catheter embolisation of the testicular vein, done by Interventional Radiologists. Varicoceles can present in childhood and adolescence with scrotal pain or discomfort, or may be subclinical.
Fiona S. Lau, John K. Pereira, Ashish Jiwane, Priya McGregor   +3 more
wiley   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

A Rare Case of Atypical Choroid Plexus Papilloma in an Adult Male Patient: A Case Report. [PDF]

Case Rep Pathol
Nisiro AM, Geremew TT.
europepmc   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, EarlyView.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model

Aging Cell, EarlyView.
Age‐related complement C3 elevation induces memory impairments and neuropathology by dysregulating astrocytic insulin signaling and triggering mitochondrial dysfunction. Critically, antibody blockade of C3 in mouse brain tissue effectively reversed learning and memory deficits in mice, demonstrating that targeting C3 is a promising therapeutic strategy.
Miaomiao Du, Yujia Wang, Xinyuan Wang, Yifei Liu, Fuchuan Xiao, Jing Zhang, Xia Meng, Kunhe Ma, Na Wu, Baian Chen, Jing Lu   +10 more
wiley   +1 more source

Retinal vessel tortuosity and fractal dimension in diabetic retinopathy. [PDF]

Int J Retina Vitreous
Fathimah FSN, Ari Widjaja S, Sasono W, Yustiarini I, Firmansjah M, Prakosa AD, Mulyazhara AK, Soelistijo SA.   +7 more
europepmc   +1 more source

Perioperative Quality Initiative consensus statement recommendations on the definition, development, implementation and outcomes of pre‐operative surgery schools

Anaesthesia, EarlyView.
Summary Introduction Pre‐operative group sessions incorporating patient education and behaviour change interventions, known as ‘surgery schools’, are becoming increasingly common before major elective surgery across the world. However, there is a lack of conclusive evidence regarding the effectiveness of surgery schools, and the development and ...
Imogen Fecher‐Jones, Ben Ainsworth, Tong J. Gan, S. Ramani Moonesinghe, Andrew D. Shaw, Michael P. W. Grocott, Denny Z. H. Levett, on behalf of the Perioperative Quality Initiative Surgery School Consensus Group, Anna M Anderson, Leah Avery, Gabriele Baldini, Angie Balfour, Rachael Barlow, Esther Carr, Daniel Conway, Robert J Copeland, Anh Dang, Andrew Davies, Mark R Edwards, Rochelle Furtado, Chelsia Gillis, Hilmy Ismail, Sandy Jack, Carol Keen, Ruth McDonald, Scarlett McNally, Zoe Merchant, Claire Moore, John Moore, Judith Partridge, Jashvant Poeran, Brocha Z Stern, Janius Tsang   +32 more
wiley   +1 more source