Results 91 to 100 of about 30,632 (260)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Sling plication for failed midurethral sling surgery to treat female stress urinary incontinence

Continence Reports
Introduction:: Stress urinary incontinence (SUI) is a common problem in women. When conservative therapy fails, surgical interventions should be considered.
Eva M.P. Remmen, John P.F.A. Heesakkers
doaj   +1 more source

Eventration of the Diaphragm

Asian Journal of Surgery, 2006
Eventration of the diaphragm (ED) is defined as the abnormal elevation of the diaphragm. Although asymptomatic ED may be amenable to conservative treatment, symptomatic ED in children, either congenital or acquired, may require surgical treatment.
Tuğrul Tiryaki, Ziya Livanelioğlu, Halil Atayurt   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Laparoscopic plication of the linea alba as a repair for diastasis recti – a mesh free approach

, 2010
Diastasis recti is a common occurrence in multiparous women (1), caused by repeated stretching of the abdominal wall by the gravid uterus. A small proportion of patients have a persisting weakness which may be symptomatic and present to the surgeon. We
C.R Kapadia, A.H Siddiky
core  

Diaphragmatic rupture after plication: Etiopathogenesis with review of the literature

, 1996
We present an infant who developed diaphragmatic rupture and secondary hernia following a successful diaphragmatic plication performed for congenital diaphragmatic eventration.
Tanyel, FERİDUN CAHİT, Hicsonmez, A, Senocak, ME, Ciftci, AO, Buyukpamukcu, N   +4 more
core   +1 more source

Ventricular volume, chamber stiffness, and function after anteroapical aneurysm plication in the sheep [PDF]

, 2000
Objective: The success of left ventricular aneurysm plication depends on how the procedure affects both end-systolic elastance and diastolic compliance and how those changes affect ventricular function (stroke work/end-diastolic volume [PRSW] and stroke ...
Wallace, Arthur W., Arthur W. Wallace, Stuart Ruch, Mark B. Ratcliffe, Salahieh, Ali, Hong, James, Timothy S. Hall, Hall, Timothy S., Ruch, Stuart, James Hong, Ali Salahieh, Ratcliffe, Mark B.   +11 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source