Results 11 to 20 of about 1,591 (177)

Graves from the Palace Centre – east site: an attempt at ethnic cultural identification of burials intra muros in Pliska

Приноси към българската археология, 2022
This study presents five graves discovered east of the Palace Centre in Pliska (fig. 1). They represent individual burials located in the inter-dwelling area (fig. 2). The graves’ contexts were studied interdisciplinarily.
Valeri Grigorov, Victoria Russeva, Nadezhda Atanassova   +2 more
doaj   +4 more sources

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Markowitz KH, Safi NV, Pliska-Bloch I, Kaunzner UW, Luu H, Sisman M, Wang Y, Nguyen TD, Hurtado Rúa S, Gauthier SA.   +9 more
europepmc   +2 more sources

Hydrophobic interactions of a substrate with L193 on the flexible substrate-binding loop contribute to 3α-hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency. [PDF]

Protein Sci
Abstract Flexible loops within enzyme active sites are central to substrate binding, transition‐state stabilization, and catalytic turnover. Hydrophobic interactions modulate ligand recognition and influence protein function. Here, we interrogated loop‐mediated hydrophobic contributions to catalysis in 3α‐hydroxysteroid dehydrogenase/carbonyl reductase
Chen YL, Chou YH, Lee HJ, Wang TP, Hwang CC.   +4 more
europepmc   +2 more sources

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence. [PDF]

Microbiologyopen
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Cunha GAD, Amaral RP, Dos Santos ALC, Aio BRF, Durante MFR, Malaquias LCC, de Freitas Almeida GM, Coelho LFL.   +7 more
europepmc   +2 more sources

Novel <i>ALG13</i> Variants and an Expanded Neurodevelopmental Spectrum: Genotype-Phenotype Correlations. [PDF]

Hum Mutat
Background The ALG13 gene is implicated in congenital disorders of glycosylation (CDG) and developmental and epileptic encephalopathy (DEE), yet genotype–phenotype correlations remain incompletely understood. Methods Whole‐exome sequencing (WES) was performed in unrelated families, and we systematically reviewed existing patient data on ALG13 variants ...
Su S, Hu W, Ren Y, Zhang T, Yu C, Zhang H.   +5 more
europepmc   +2 more sources

Insights into ANKRD11-related epilepsy from 163 people. [PDF]

Epilepsia
Abstract Objective Ankyrin repeat domain 11 gene (ANKRD11) is the key disease gene for autosomal dominant KBG syndrome, and a subset of affected individuals develop epilepsy. However, comprehensive characterization of epilepsy‐related phenotypes and genotype–phenotype correlations in ANKRD11 variant carriers remains limited.
Su S, Ma J, Zhang Q, Hu W, Ren Y, Zhang W, Zhang H.   +6 more
europepmc   +2 more sources

Prevalence of Altered Craniofacial Morphology in Children With OSA. [PDF]

J Sleep Res
ABSTRACT Snoring and obstructive sleep apnoea (OSA) affect a significant percentage of children. Recent studies have suggested that altered craniofacial morphology may contribute to the multifactorial pathophysiology of OSA. This study aims to determine the prevalence of craniofacial abnormalities and malocclusion in children referred for ...
Huynh N, Zhang J, Pliska B, Amin R, Narang I, Chadha N, Cholette MC, Kirk V, Montpetit A, Vezina K, Jacob S, Laberge S, Hamoda M, Almeida F.   +13 more
europepmc   +2 more sources

STXBP1 Variants Associated With Epilepsy With Variable Severity. [PDF]

CNS Neurosci Ther
STXBP1‐related disorders range from mild epilepsy to DEE, and severity aligns with impact on structure and Munc18‐1 abundance. Noncore inherited variants are stable with preserved Munc18‐1 and a favorable prognosis, whereas de novo core variants reduce Munc18‐1, causing severe seizures, neurodevelopmental deficits, and poorer outcomes.
Xu M, Guo X, Wang ZK, Qi Y, Ye TT, Xu J, Deng WW, Zhuang MZ, Shi YW, Xiong F, Liu XR, China Epilepsy Gene 1.0 Project.   +11 more
europepmc   +2 more sources

Pliska – Dünnschliffanalysen gelber Keramik und anderer frühmittelalterlicher Keramikarten aus einem Geheimgang des »Krum- Palastes« und von benachbarten Fundstellen

, 2018
Pliska – Thin-Section Analysis of Yellow Pottery and Other Early Medieval Pottery Groups from a Secret Passage of »Krum’s Palace« and Neighbouring SitesThis article presents results of the analysis of 23 thin sections of early medieval pottery from ...
Herold, H
core   +7 more sources

Kabiyuk: another Pliska?

, 2007
Joachim Henning, Eyup F. Eyup
exaly   +2 more sources