Results 141 to 150 of about 22,535 (282)

FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking

Nature Communications
Fusion oncoproteins, a class of chimeric proteins arising from chromosomal translocations, are major drivers of various pediatric cancers. These proteins are intrinsically disordered and lack druggable pockets, making them highly challenging therapeutic ...
Sophia Vincoff, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, Pranam Chatterjee   +5 more
doaj   +1 more source

Influence of the post‐processing protocol on a biocompatible 3D‐printed resin

Journal of Prosthodontics, EarlyView.
Abstract Purpose This study aimed to evaluate the cytotoxicity of a biocompatible 3D‐printed resin material for occlusal devices after post‐processing with two different high‐intensity UV‐polymerization devices and two rinsing solvents, in the presence of human gingival fibroblasts (HGFs).
Sergio López‐García, Miguel Ramón Pecci‐Lloret, María Pilar Pecci‐Lloret, David García‐Bernal, Ricardo Elías Oñate‐Sánchez   +4 more
wiley   +1 more source

The dynamics of cyclic‐periodic phenomena during non‐rapid and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is a complex physiological state characterized by distinct stages, each exhibiting unique electroencephalographic patterns and physiological phenomena. Sleep research has unveiled the presence of intricate cyclic‐periodic phenomena during both non‐rapid eye movement and rapid eye movement sleep stages. These phenomena encompass a spectrum
Maria P. Mogavero, Lourdes M. DelRosso, Giuseppe Lanza, Oliviero Bruni, Luigi Ferini Strambi, Raffaele Ferri   +5 more
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Introduction Of Plm

, 2017
In industry, product lifecycle management (PLM) is the process of managing the entire lifecycle of a product from inception, through engineering design and manufacture, to service and disposal of manufactured products. PLM integrates people, data, processes and business systems and provides a product information backbone for companies and their ...
openaire   +2 more sources

S‐PLM: Structure‐Aware Protein Language Model via Contrastive Learning Between Sequence and Structure

Advanced Science
Proteins play an essential role in various biological and engineering processes. Large protein language models (PLMs) present excellent potential to reshape protein research by accelerating the determination of protein functions and the design of ...
Duolin Wang, Mahdi Pourmirzaei, Usman L. Abbas, Shuai Zeng, Negin Manshour, Farzaneh Esmaili, Biplab Poudel, Yuexu Jiang, Qing Shao, Jin Chen, Dong Xu   +10 more
doaj   +1 more source

Sex‐based disparities in dopamine agonist response in patients with restless legs syndrome

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary This study aimed to investigate sex‐related differences in the response to ropinirole and pramipexole in patients with restless legs syndrome (RLS). By analysing clinical parameters and polysomnographic (PSG) findings, we sought to elucidate the potential factors related to sex disparities modulating treatment responses and sleep quality in RLS.
Maria P. Mogavero, Elena Antelmi, Giuseppe Lanza, Sara Marelli, Alessandra Castelnuovo, Michele Tinazzi, Lourdes M. DelRosso, Rosalia Silvestri, Raffaele Ferri, Luigi Ferini Strambi   +9 more
wiley   +1 more source

Sleep Disordered Breathing Severity Alters Overnight Temperature Changes in Children

Journal of Sleep Research, EarlyView.
ABSTRACT The quality of sleep is very closely related to variations in body temperature. We aimed to assess the feasibility of skin temperature measurements in children attending the sleep laboratory for routine polysomnography and to determine whether there was a difference in body temperature between children with different severities of sleep ...
Georgina Plunkett, Marisha Shetty, Maria Vaz‐Serra, Stephane Delanaud, Lauren C. Nisbet, Margot J. Davey, Gillian M. Nixon, Rosemary S. C. Horne, Veronique Bach   +8 more
wiley   +1 more source

Phenotype Refinement Influences GWAS‐Implicated Variant Effect Sizes for Insomnia

Journal of Sleep Research, EarlyView.
ABSTRACT How phenotypes are measured, especially when relying on subjective reports, is an impediment to the utility of genome‐wide association studies (GWAS). This is a common problem in GWAS for sleep traits, as many sleep disturbances appear subjectively similar despite having distinct underlying pathophysiology.
Amber J. Zimmerman, Patrick Z. Liu, Brendan T. Keenan, Thomas G. Brooks, Struan F. A. Grant, Philip R. Gehrman, Ron C. Anafi, Allan I. Pack   +7 more
wiley   +1 more source

Radicalising your Lifecycle’s full potential with PLM

‘The Radicalising your Lifecycle’s full potential with PLM’ was hosted by University of Huddersfield and ITC Infotech as part of Inspired Huddersfield 2016.
Conlon, Jo, Taylor, Andrew, ITC Infotech UK   +2 more
core