Results 151 to 160 of about 12,551 (327)

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.
What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Comparative analysis of intermuscular bones in fish of different ploidies [PDF]

, 2013
Jun Wang, Jun Xiao, Ling Li, Ming Zeng, ShaoJun Liu, Yi Zhou, Yun Liu, ZeZhou Zhong   +7 more
core   +1 more source

A high‐recovery, high‐density targeted genotyping platform for cranberry

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract The American cranberry (Vaccinium macrocarpon) is a commercially important berry species native to North America. Cranberry is a popular fruit crop with many known health benefits. Thus far, genotyping‐by‐sequencing (GBS) was the only high‐throughput genotyping technique available in cranberry.
Shaun J. Clare, Ping Zheng, Mandie Driskill, Joseph Kawash, Jeffrey Neyhart, Timothy R. Millar, Dorrie Main, James Polashock, Patrick Edger, Nicholi Vorsa, Jennifer Johnson‐Cicalese, Andrew F. Maule, Juan Zalapa, Gina M. Sideli, Massimo Iorizzo, Nahla Bassil   +15 more
wiley   +1 more source

Potato dihaploids uncover diverse alleles to facilitate diploid potato breeding

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Commercial potato (Solanum tuberosum) in North America is a clonal autotetraploid crop, which complicates breeding. Efforts are underway to convert potato to a diploid inbred‐hybrid crop, allowing breeders to more quickly meet market and environmental demands.
Sapphire Coronejo, Brieanne Vaillancourt, John P. Hamilton, Xiaoxi Meng, Kathrine Mailloux, Grace Christensen, Jessica Huege, Kathleen M. Shaw, Husain I. Agha, Oluwafemi Alaba, Kristen Brown‐Donovan, James S. Busse, Andy Hamernik, Maria V. Caraza‐Harter, Lucas Heroux, Hemant Balasaheb Kardile, Ericka Knoeck, Peyton L. Sorensen, Diana Spencer, Solomon Yilma, Paul C. Bethke, David Douches, Joshua Parsons, Vidyasagar Sathuvalli, Ek Han Tan, Jeffrey B. Endelman, C. Robin Buell, Laura M. Shannon   +27 more
wiley   +1 more source

Ploidy [PDF]

, 2011
openaire   +2 more sources

First whole genome sequence of a diploid crop wild relative of the Andean tuber “oca”: Annotation and comparative genomic analysis of Oxalis oulophora

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Oxalis oulophora, a diploid species closely related to the octoploid Andean tuber crop oca (Oxalis tuberosa), was selected for whole‐genome sequencing to aid in understanding the origins of polyploidy and domestication in oca and its relatives (crop wild relatives).
Dilrini Vanrooyen, Eve Emshwiller
wiley   +1 more source

Nuclear fusions contribute to polyploidization of the gigantic nuclei in the chalazal endosperm of Arabidopsis [PDF]

, 2018
Somatic polyploidization is recognized as a means to increase gene expression levels in highly active metabolic cells. The most common mechanisms are endoreplication, endomitosis and cell fusion.
Baroux, Célia, Fransz, Paul, Grossniklaus, Ueli   +2 more
core  

InferPloidy: Fast and accurate ploidy inference enables inter-tumoral biomarker discovery in single-cell RNA-seq datasets [PDF]

Wing‐Kin Sung, Jeong‐Ho Chae, Jucheol Moon, Seokhyun Yoon, Jong-chan Lee, Sunjoo Jeong, Seokhyun Yoon   +6 more
openalex   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Whole-Genome Duplication Reshapes Adaptation: Autotetraploid Arabidopsis arenosa Leverages its High Genetic Variation to Compensate for Selection Constraints. [PDF]

Mol Biol Evol
Celestini S, Lipánová V, Vlček J, Kolář F.   +3 more
europepmc   +2 more sources