Results 161 to 170 of about 72,449 (297)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The Expression and Clinical Significance of ALDOA in Breast Cancer. [PDF]

Onco Targets Ther
Dai Y, Yang Y, Li X, Shi G, Ni T, Zhu Q, He Q, Hu A, Jiang H, Liu J, Lu T, Sun J, Yu E, Sun L.   +13 more
europepmc   +1 more source

Principal Coordinate Analysis (PCoA) plot for water samples by water source and season in Carriacou.

Akilah T. M. Stewart (9243473), Adrian Cashman (6180024), John Agard (20170071), Dave Chadee (21956940), Adesh Ramsubhag (6697457)   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Scatter plots showing the relationships between pairs of parameters in the posterior sample for the human model.

Bevelynn Whaler (22305512), Grant Lythe (5485931), Joseph J. Gillard (5485934), Thomas R. Laws (8739726), Jonathan Carruthers (5485928), Thomas Finnie (9600412), Carmen Molina-París (4989545), Martín López-García (4989548)   +7 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Clinicopathologic and prognostic significance of TIAM2 overexpression in resected hepatocellular carcinoma. [PDF]

Future Sci OA
Lu J, Li L, Chen Q, Li B, Ren S, Yuan M, Meng M, Lei J, Bing Y, Wang H, Guo L, Ma Z, Xiu D, Yuan C.   +13 more
europepmc   +1 more source

List of trees in 20.75 ha of plots in eight locations around Ibu Kota Negara, East Kalimantan, Indonesia.

Tri Atmoko (21021175), Bina Swasta Sitepu (21021178), Wahyu Catur Adinugroho (21021181), Mukhlisi (21021184), Tri Sayektiningsih (21021187), Titiek Setyawati (2904629), Francis Q. Brearley (6621473), Ishak Yassir (17225689)   +7 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Roles of organic anion transporting polypeptides in hepatocellular carcinoma. [PDF]

Front Genet
Chen H.
europepmc   +1 more source