Results 61 to 70 of about 829,101 (387)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Advanced analysis and visualization of gene copy number and expression data

BMC Bioinformatics, 2009
Background Gene copy number and gene expression values play important roles in cancer initiation and progression. Both can be measured with high-throughput microarrays and some methodologies to integrate and analyze these data exist.
Hautaniemi Sampsa, Järvinen Anna-Kaarina, Saarela Matti, Autio Reija, Astola Jaakko   +4 more
doaj   +1 more source

System remotely inspects, measures, and records internal irregularities in piping [PDF]

, 1968
Video electromechanical probe visually inspects and measures internal offset and peaking of welds in relatively large piping. Irregularity dimensions are recorded on peripheral equipment consisting of video tape and X-Y plotter.
Burry, F. H., Cunningham, J. Y., Heisman, R. M., Iceland, W. F., Norwood, L. B.   +4 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The role of complement in the clinical course of hepatocellular carcinoma

Immunity, Inflammation and Disease, 2022
Background The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in different kinds of cancer. The function of complement in hepatocellular carcinoma (HCC) is unclear.
Xinye Qian, Zhoujing Yang, Lu Gao, Yipiao Liu, Jun Yan   +4 more
doaj   +1 more source

Calibration standard for dynamic evaluation of a profile-plotter [PDF]

, 1969
Template is used for evaluation of the dynamic characteristics and accuracy of the plotter. It has a profile composed of surfaces parallel to and at known distances from a reference plane, plane, the diverse surfaces being connected by slopes of known ...
Moulton, K. S.
core   +1 more source

Particle Event Generator: A Simple-in-Use System PEGASUS version 1.0

, 2019
PEGASUS is a parton-level Monte-Carlo event generator designed to calculate cross sections for a wide range of hard QCD processes at high energy $pp$ and $p\bar p$ collisions, which incorporates the dynamics of transverse momentum dependent (TMD) parton ...
Baranov, S. P., Lipatov, A. V., Malyshev, M. A.   +2 more
core   +1 more source

J-Circos: an interactive Circos plotter

Bioinform., 2015
SUMMARY Circos plots are graphical outputs that display three dimensional chromosomal interactions and fusion transcripts. However, the Circos plot tool is not an interactive visualization tool, but rather a figure generator.
Jiyuan An, J. Lai, Atul Sajjanhar, J. Batra, Chenwei Wang, C. Nelson   +5 more
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source