Results 31 to 40 of about 32,817 (185)

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Age‐Dependent Prognostic Significance of Preoperative Transthyretin After Curative Resection for Stage I–III Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Preoperative malnutrition and systemic inflammation are established determinants of adverse outcomes in colorectal cancer (CRC). Transthyretin (TTR), a rapid‐turnover hepatic protein, reflects both nutritional and inflammatory status; however, its clinical utility may be influenced by age‐ and sex‐related variability.
Ayane Kawata, Yuji Miyamoto, Hiro Nakamura, Takahiko Akiyama, Kota Arima, Katsuhiro Ogawa, Yukiharu Hiyoshi, Masaaki Iwatsuki   +7 more
wiley   +1 more source

Male reproductive system in stenopodidean shrimps: Unveiling basal reproductive traits in shrimp‐like Pleocyemata (Stenopodidae and Spongicolidae)

The Anatomical Record, EarlyView.
Abstract Stenopodidea represents one of the basal lineages within Pleocyemata, yet the male reproductive system (MRS) of this group remains poorly understood, with limited information available regarding its morphology and function. This study provides the first detailed description of the MRS in four stenopodidean shrimp species from two families ...
Caio Santos Nogueira, Lucas Rezende Penido Paschoal, Fernando José Zara   +2 more
wiley   +1 more source

Evaluation of prognostic markers in patients infected with SARS-CoV-2

Open Life Sciences, 2022
Prognostic markers are the biomarkers used to measure the disease progression and patient outcome regardless of treatment in coronavirus disease 2019 (COVID-19).
Mandal Dipendra Kumar, Chhusyabaga Mandira, Pokhrel Sushant, Bhattarai Bibek Raj, Aryal Suraj, Nepal Richa, Bastola Anup, Baral Soma Kanta, Bhatt Mahendra Prasad, Marahatta Sujan Babu, Sah Shiv Kumar   +10 more
doaj   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Diagnostic utility of laboratory parameters in COVID 19 patients

Journal of Dr. NTR University of Health Sciences
Background: Several pneumonia cases caused by new corona virus were reported in Wuhan, China, since December 2019. This evolved into global pandemic and the World Health Organization (WHO) named this virus as severe acute respiratory syndrome corona ...
Rizwana Shaik, Ramya Potti, Renuka I. Venkata, Anusha Mullagura, Siri C. Chadalavada   +4 more
doaj   +1 more source

A New Index AGR-PLR Score (APS) for Patients with Esophageal Squamous Cell Carcinoma Undergoing Radical Esophagectomy

Cancer Management and Research, 2021
Yimin Yao, Chang Cai, Fei Sun, Wei Gong Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, People’s Republic of ChinaCorrespondence: Wei GongDepartment of Radiation Oncology, The First Affiliated ...
Yao Y, Cai C, Sun F, Gong W
doaj  

When and How Do Women Directors Matter for Corporate Sustainability? The French Case

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines when and how board gender diversity matters for corporate sustainability. Using a sample of French listed firms over 2006–2024, we combine dynamic system GMM estimations with difference‐in‐differences tests around France's phased board gender quotas.
Amandeep Mattoo, Pascal Nguyen
wiley   +1 more source

The Value of Systemic Inflammation Indices in Predicting Survival in Critical Flame Burn Patients: A Single-Center Retrospective Analysis

Hamidiye Medical Journal
Background: Burns are an important health problem that causes serious morbidity and mortality all over the world. Mortality in patients with critical burns is related to factors such as age, inhalation injury, and total burn surface area (TBSA).
Feyyaz Güngör, Hüseyin Kılavuz, Oğuzhan Aytepe, Mehmet Kuluş, Ceren Gökduman, Mustafa Turan   +5 more
doaj   +1 more source

Diagnostic Value of Peripheral Blood NLR and PLR in Gastrointestinal Pancreatic Neuroendocrine Neoplasm

Zhongliu Fangzhi Yanjiu, 2019
Objective To explore the diagnostic value of peripheral blood NLR and PLR in gastrointestinal pancreatic neuroendocrine neoplasm. Methods Blood cell analyzer was used to detect peripheral blood cell parameters of 95 cases pathologically diagnosed as GEP ...
ZHAO Ran, SHI Ruihua
doaj   +1 more source