Results 91 to 100 of about 224,914 (338)

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

Advanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang, Fengzhi Qiao, Jian He, Jianxin Fu, Tongjie Liu, Huaxi Yi, Qinghai Sheng, Lanwei Zhang, Kai Lin   +8 more
wiley   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Soil Nutrient Enrichment Induces Trade‐Offs in Bacterial Life‐History Strategies Promoting Plant Productivity

Advanced Science, EarlyView.
Soil nutrient enrichment induces the trade‐offs between bacterial functional potential and growth‐rate potential. Such trade‐offs favor specific plant‐beneficial species and genes, playing a pivotal role in determining plant productivity. These findings enhance the understanding of the microbial responses in agroecosystems to ongoing global ...
Yuanyuan Yan, Xing Zhou, Liangliang Liu, Zucong Cai, Josep Penuelas, Xinqi Huang   +5 more
wiley   +1 more source

Model‐Guided Systematic Metabolic Engineering for Enhanced Spinosad Biosynthesis in Saccharopolyspora spinosa NHF132

Advanced Science, EarlyView.
A genome‐scale model guided the systematic metabolic engineering of Saccharopolyspora spinosa, enabling a 5.5‐fold boost in the green bioinsecticide spinosad to 1.8 g L−1 and establishing an actinomycete framework for complex natural products overproduction.
Shuliu Wang, Yuxin Liu, Qian Zhang, Yue Jiang, Xiaoqian Zeng, Chengyu Zhang, Jiagao Cheng, Weishan Wang, Lixin Zhang, Gao‐Yi Tan   +9 more
wiley   +1 more source

Physical and Commercial Geography: A Study of Certain Controlling Conditions of Commerce . By H. E. Gregory, A. G. Keller and A. Il. Bishop, Professors in Yale University. 8vo. Pp. viii + 469; figs. 26, pls. 3. Boston, Ginn & Co. 1910. $3.00. [PDF]

, 1910
J. Paul Goode
openalex   +1 more source

Improving PLS-SEM use for business marketing research

Industrial Marketing Management, 2023
Peter Guenther, Miriam Guenther, C. Ringle, Ghasem Zaefarian, Severina Cartwright   +4 more
semanticscholar   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

Advanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
wiley   +1 more source

Revision of the Palæocrinoidea.—Part III. Discussion of the classification and relations of the brachiate Crinoids, and conclusion of the generic descriptions. By Charles Wachsmuth and Frank Springer. First Section. Extracted from the ‘Proceedings of the Academy of Natural Sciences,’ July 28, 1885. Philadelphia, 1885. Pp. 138, pls. iv.–ix. [PDF]

, 1886
P. Herbert Carpenter
openalex   +1 more source