Results 121 to 130 of about 1,202 (247)

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Cryo‐EM Analysis of Adenovirus Vector Reveals Purification Conditions Leading to Loss of Viral Fiber Proteins and Reduced Infectivity

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Vaccines and gene therapies require efficient delivery of genetic material to host cells. Viral vectors leverage viruses' ability to enter host cells to achieve this. Following the SARS‐CoV‐2 vaccine and novel gene therapies that utilize adenovirus vectors, there has been an increase in the demand for large‐scale production of vectors.
Betsy Widdicombe, Joseph D. Barritt, Nichakorn Pipatpadungsin, Braulio Carrillo Sanchez, Dale Stibbs, Lisa Cooper, Sarah L. Rouse, Daniel G. Bracewell   +7 more
wiley   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Mitigating Goodhart's law in epitope-conditioned TCR generation using plug-and-play reward designs. [PDF]

Bioinformatics
Zhang P, He X, Guan F, Mei H, Grama G, Bang S, Lee H.   +6 more
europepmc   +1 more source

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

HiCP2GAN: a plug and play foundation model-based GAN for Hi-C enhancement. [PDF]

Brief Bioinform
Olowofila S, Oluwadare O.
europepmc   +1 more source

Circular Innovations in Complex Systems: A Blueprint of Four Design Archetypes

Business Strategy and the Environment, EarlyView.
ABSTRACT Circular innovations (CI), defined as the redesign of products, services or practices to minimise waste, reduce resource use and regenerate natural systems, are essential for advancing the circular economy. Despite growing recognition, their deployment in systems of linked parts with unpredictable interactions (complex systems) remains limited
Sophie Führer, Lucas Miehé, Catharina Bening   +2 more
wiley   +1 more source

CONSISTENCY MODELS FOR FAST MRI USING REGULARIZATION BY DENOISING. [PDF]

Proc IEEE Int Symp Biomed Imaging
Gülle M, Yun J, Alçalar YU, Akçakaya M.   +3 more
europepmc   +1 more source

From Waste to Worth: The Case for Modular and Upgradable Electronics in a Sustainable Future

Business Strategy and the Environment, EarlyView.
ABSTRACT The rapid obsolescence of electronic products poses a major challenge to sustainable development due to rising e‐waste. Modular and upgradable product (MUP) architectures offer a promising approach to extend product lifetimes and reduce environmental impact. This study investigates how consumer perceptions and behaviours affect the adoption of
Mees Groothuis, Negin Salimi
wiley   +1 more source

DeStyle: A Unified Decoupled Framework for Style Transfer via Singular Value Purification and Attention-Guided Distillation. [PDF]

J Imaging
Liu X, Xian T, Geng X, Zhao D, Liu W.
europepmc   +1 more source