Results 151 to 160 of about 298,479 (352)

Assessment of analytical and experimental techniques utilized in conducting plume technology tests 575 and 593 [PDF]

open access: yes
Since exhaust plumes affect vehicle base environment (pressure and heat loads) and the orbiter vehicle aerodynamic control surface effectiveness, an intensive program involving detailed analytical and experimental investigations of the exhaust plume ...
Baker, L. R.   +3 more
core   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

open access: yesAdvanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei   +32 more
wiley   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

open access: yesAdvanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li   +9 more
wiley   +1 more source

Numerical Study on the Influence of Separation Time Sequence on the Initial Thermal Separation

open access: yesEnergies
The process of separating stages is crucial for multistage rockets, directly influencing the success of the launch plan. Different separation timing methods alter the flow field structure within the interlevel zone at separation, influencing the ...
Chenhui Ma, Sihang Wang, Jianyang Yu
doaj   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello   +10 more
wiley   +1 more source

A Sub‐1 Nm Cluster Chains‐enhanced Poly(ethylene oxide) Electrolyte for an All‐solid‐State Lithium Metal Battery with a Long Cycling Lifespan

open access: yesAdvanced Science, EarlyView.
Sub‐1 nm inorganic cluster chain with cation vacancies optimize PEO electrolytes by eliminating Li+ migration barriers and constructing 3D ion transport networks, while in situ c‐AFM reveals dynamic transport mechanisms, enabling high‐performance all‐solid‐state batteries. Abstract Flexible composite polymer electrolytes (CPEs) are promising candidates
Shanshan Song   +8 more
wiley   +1 more source

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