Results 101 to 110 of about 598,821 (278)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Population management of cone and seed insects in spruce seed orchards [PDF]

, 2011
Seed orchards have been established in order to produce high quality seeds for reforestation and forestation. However, seed production in spruce (Picea abies (L.) Karst.) seed orchards is severely hampered by cone- and seed-feeding insects.
Rosenberg, Olle
core  

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Damage caused by Lophodermium needle cast in open-pollinated and control-crossed progeny trials of Scots pine (Pinus sylvestris L.)

The Forestry Chronicle, 2018
The effect of genetics on the level of damage caused by Lophodermium needle cast to Scots pine was assessed in an openpollinated progeny trial (226 families from 12 provenances) and in a control-crossed progeny trial (72 families obtained by diallel ...
Una Neimane, Kaspars Polmanis, Astra Zaļuma, Dārta Kļaviņa, Tālis Gaitnieks, Āris Jansons   +5 more
doaj   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

The Effects of a Fungal Biocontrol Agent and a Chemical Adjuvant on the Efficacy of Cuprous Oxide Sprays for Controlling Witches’ Broom Disease in Cocoa

Journal of Agricultural and Marine Sciences, 2000
A Field experiment was carried out in a cocoa plantation in Brazil to evaluate whether a fungal biocontrol agent (Trichoderma spp.) and a chemical adjuvant could enhance the efficacy of cuprous oxide sprays that are applied to control witches’ broom ...
J.R.M. Thacker, L.V. Laine, R.D. McLean
doaj   +1 more source

Bayesian Causal Induction

, 2011
Discovering causal relationships is a hard task, often hindered by the need for intervention, and often requiring large amounts of data to resolve statistical uncertainty. However, humans quickly arrive at useful causal relationships. One possible reason
Ortega, Pedro A.
core  

Genetic Diversity of Acacia Crassicarpa A. Cunn. Ex Benth.Plus Trees of a Provenance Trial in Serdang, Malaysia [PDF]

, 1999
In the selection of the best species for forest plantation, few criterias have to be considered including morphological and genetic diversity. Thus, the objective of this study was to investigate the diversity of Acacia crassicarpa plus trees using ...
Chubo, John Keen
core  

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source