Results 91 to 100 of about 2,274,005 (214)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Quantitative evaluation of China’s commercial health insurance policies based on the policy modeling consistency index model

BMC Health Services Research
Objective This study aims to quantitatively evaluate China’s commercial health insurance (CHI) policies and provide a reference for improving the policy.
Liujin Zhang, Wenwen Ma, Chao Zheng, Jiling Song, Qiang Sun, Jia Yin   +5 more
doaj   +1 more source

Seminars in epileptology: Holistic management of epilepsy in adults with intellectual development disorders

Epileptic Disorders, EarlyView.
Abstract This seminar addresses the complexity of the management of epilepsy in adults with intellectual development disorders (IDD), advocating holistic and multidisciplinary care aligned with the learning objectives of the International League Against Epilepsy. Epilepsy is significantly more prevalent in people with IDD, presenting unique diagnostic,
Elena Fonseca, Antonella Riva, Samuel López‐Maza, Malin Zaddach, Marie‐Claire Porter, Ingo Borggraefe, Lance Watkins, Andreas Schulze‐Bonhage, Rohit Shankar, Pasquale Striano, Lina Nashef   +10 more
wiley   +1 more source

Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy

Epilepsia, EarlyView.
Abstract Objective In patients with drug‐resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real‐time biomarkers.
Zachary T. Sanger, Xinbing Zhang, Thomas Lisko, Hafsa Farooqi, Steffen Ventz, Sandipan Pati, Thomas R. Henry, David P. Darrow, Michael C. Park, Theoden I. Netoff, Robert A. McGovern   +10 more
wiley   +1 more source

Dynamics of social and cultural institutions in AI governing: a PMC study based on China’s AI policy

Data & Policy
This study focuses on a multidimensional evaluation of China’s artificial intelligence (AI) governance policies by employing the Policy Modeling Consistency (PMC) index model to systematically analyze the performance and coherence of these policies in ...
Chen Qu, Xinyang Zhao, Xuefang Xie
doaj   +1 more source

Intertwin birth weight discordance, mode of delivery, and fetal and neonatal outcomes in twin pregnancies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of the present study was to evaluate the association between intertwin birth weight discordance and fetal and neonatal outcomes in twin pregnancies, and to assess its relationship with mode of delivery. Methods This retrospective cohort study included twin pregnancies delivered at a tertiary referral center.
Ana Martínez‐Zarco, Javier Sánchez‐Romero, José Eliseo Blanco‐Carnero, Paz Crespo‐Bañón, Romina Sol Liandro, Miriam Pertegal‐Ruiz, Walter Plasencia‐Acevedo, Aníbal Nieto‐Díaz, Catalina de Paco‐Matallana   +8 more
wiley   +1 more source

Reliability evaluation of hierarchical hypercube network

Tongxin xuebao, 2021
Aiming at the problem that the reliability research on hierarchical hypercube networks was not yet systematic, which severely restricted its application and popularization, the hierarchical hypercube network was taken as studying object, on the basis of ...
Ximeng LIU, Yufang ZHANG, Shuming ZHOU, Xiaoyan LI   +3 more
doaj   +2 more sources

Experiment in resilient city: An evaluation of China’s demonstration city of safe development policies

Heliyon
The drive of resilient city explores a new path for urban governance in the context of risk society, and China’s demonstration city of safe development (DCSD) policies are the indigenous practice of resilient city idea.
Juan Liu, Chengli Wang, Rui Zhang
doaj   +1 more source

Medical Reasoning With Large Language Models: A Systematic Review and Evaluation

iNew Medicine, EarlyView.
ABSTRACT Large language models (LLMs) have achieved strong performance on medical exam–style tasks, motivating growing interest in their deployment in real‐world clinical settings. However, clinical decision‐making is inherently safety‐critical, context‐dependent, and conducted under evolving evidence.
Xiaohan Ren, Chenxiao Fan, Wenyin Ma, Hongliang He, Chongming Gao, Xiaoyan Zhao, Fuli Feng   +6 more
wiley   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source