Results 91 to 100 of about 41,654 (227)

Marketization in Public Purchasing as a Route to Business Corporations' Institutional Power: The Case of Outsourcing Social Services in Israel

Policy Studies Journal, EarlyView.
ABSTRACT What are the conditions under which business corporations expand their institutional power? This paper argues that institutional power is affected by the architecture of the “acquisition regime”—the set of formal (and informal) rules that govern how states purchase public services.
Reut Marciano, Shir Gal
wiley   +1 more source

La regulación peruana del régimen de plazos en las APP: consideraciones para su estructuración e incidencias económico-financieras de su ruptura

Thēmis
El presente trabajo académico analiza y reconoce la relevancia de la regulación del elemento temporal en los contratos suscritos para la ejecución de proyectos de asociaciones público privadas, así como intenta explicar cómo dicho elemento llega a ...
Renzo Orlando Salazar Carpio
doaj  

Exercise‐induced dynamic hyperinflation in chronic obstructive pulmonary disease

Experimental Physiology, EarlyView.
Abstract Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease caused by inhalation of noxious particles, most commonly cigarette smoking. The consequent changes in airways, lung parenchyma and pulmonary vasculature lead to increased resistive, elastic and threshold loads and impaired capacity of the respiratory muscle pump. COPD
Rebecca F. D'Cruz, Dominic Wilkins, Caroline J. Jolley   +2 more
wiley   +1 more source

Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice

Molecular Therapy: Nucleic Acids, 2018
Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery.
Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu   +4 more
doaj   +1 more source

Kinerja Pengawas Menelan Obat (PMO) Penderita TB Paru BTA+ di Puskesmas I Denpasar Selatan Tahun 2012 [PDF]

, 2014
Penyakit TB Paru adalah penyakit menular yang disebabkan oleh kuman Mycobacterium tuberculosis. Puskesmas I Denpasar Selatan merupakan Puskesmas dengan kejadian TB Paru BTA+ paling tinggi. Hampir semua pasien tuberkulosis mempunyai pengawas menelan obat (
Lupitayanti, L. E. (Luh)
core  

Cerebral haemodynamic responses to inspiratory muscle work

Experimental Physiology, EarlyView.
Abstract Fatiguing inspiratory work has been shown to evoke a sympathetically mediated reflex that has systemic cardiovascular consequences, including increases in heart rate and blood pressure and a decrease in resting limb vascular conductance. Moreover, the response to this reflex appears to be attenuated in females compared with males.
Andrew H. Ramsook, Morgan A. Hughes, Wyatt W. Pruter, Kevin L. Webb, Ali Ataie, Chad C. Wiggins, Gabrielle A. Dillon, Sarah E. Baker, Michael J. Joyner   +8 more
wiley   +1 more source

A Right‐Wing Populist Turn in the Conservative Party of Canada? Continuities and Ruptures Under the Leadership of Pierre Poilievre (2022–2025)

Canadian Review of Sociology/Revue canadienne de sociologie, Volume 63, Issue 2, May 2026.
ABSTRACT Since his election as leader of the Conservative Party of Canada (CPC) in 2022, Pierre Poilievre has been associated with populism in media and political discourse, with implicit and explicit comparisons to Donald Trump. This article investigates the validity of such assessments by applying “complex” theories of populism, which conceptualize ...
Efe Peker, Emily Laxer, Rémi Vivès
wiley   +1 more source

Lack of GPNMB Is Associated With Altered Lipid and Glucose Metabolism and Disrupted Diurnal Hepatic Glycogen Regulation

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Loss of GPNMB function in mice fed a high‐fat/high‐fructose diet aggravated adiposity and dyslipidemia while preserving systemic glucose tolerance. This phenotype was associated with impaired hepatic AKT–FOXO1 signaling, increased NF‐κB activation, altered glycogen metabolism, and rhythmic disturbances in energy expenditure and clock gene expression ...
Eliz Maria de Oliveira Furtado, Lina Jegodzinski, Juliano Jefferson da Silva, Ana Flávia Tostes, Lucas dos Santos, Pietra Souza Barsanele, Beatriz Santana‐Lima, Luciana Chagas Caperuto, Mery Natali Silva Abreu, Darko Castven, Andrea Schenk, Danusa Soares Dias, Jens U. Marquardt, Maristela Oliveira Poletini, Leonardo Vinícius Monteiro de Assis, Maria Nathália Moraes   +15 more
wiley   +1 more source

Production of four Neurospora crassa lytic polysaccharide monooxygenases in Pichia pastoris monitored by a fluorimetric assay

Biotechnology for Biofuels, 2012
Background Recent studies demonstrate that enzymes from the glycosyl hydrolase family 61 (GH61) show lytic polysaccharide monooxygenase (PMO) activity.
Kittl Roman, Kracher Daniel, Burgstaller Daniel, Haltrich Dietmar, Ludwig Roland   +4 more
doaj   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source