Results 81 to 90 of about 41,654 (227)

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

El Desarrollo de Infraestructura Pública y los acuerdos de Estado a Estado: Alcances y Oportunidades

Derecho & Sociedad, 2020
Uno de los factores claves para mejorar la competitividad de un país es el desarrollo de la infraestructura pública, promueve el crecimiento y permite su sostenibilidad, pero su ejecución debe ser planificada y adecuada a las necesidades actuales y ...
Villafranqui Rivera, Giancarlo
doaj  

Managing Information Across the Enterprise: Implementing a Program Management Office (PMO) [PDF]

, 2015
Program management offices (PMOs) can help develop and implement organizational improvements. PMOs can increase the efficiency and effectiveness of product and service delivery and help bridge the strategy–execution gap to sustain a competitive advantage.
Jankovic, Edward M., Lohle, Michael F., Terry, Kathleen Y.   +2 more
core  

How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse [PDF]

, 2015
Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of dystrophin protein. Despite this, the relationship between restoring dystrophin to established dystrophic muscle and its ability to ...
Betts, C, Coursindel, T, El Andaloussi, S, Gait, M J, Godfrey, C, Hammond, S, Hildyard, J C W, McClorey, G, Muses, S, O'Donovan, L, Terry, R L, Wells, D J, Wells, K E, Wood, M J   +13 more
core   +2 more sources

Generative AI Implementation in Enterprises: Lessons From a Case Study of Enhanced IT Service Management

Information Systems Journal, EarlyView.
ABSTRACT The recent rise of Generative Artificial Intelligence (GenAI) is fundamentally changing the way businesses operate, with many now investing heavily in this technology. However, businesses are still exploring ways to extract value from GenAI and develop organisational capabilities.
Ashish Jagdish Sharma, Bhawana Rathore, Baidyanath Biswas, Xiao Xiao, Rohit Gupta   +4 more
wiley   +1 more source

When Do Sustainability Tensions Harm or Benefit Innovation Portfolios? A Paradoxical Perspective

Journal of Product Innovation Management, EarlyView.
ABSTRACT The coexistence of a competitive and sustainability strategy often introduces tensions within organizations. These tensions, if not appropriately managed, can lead to defensiveness and destruction, while they also have the potential to drive creativity and foster sustainability.
Jadena Bechtel, Luca Sabini, Alexander Kock   +2 more
wiley   +1 more source

Determination of the oxidative stability of perfluoropolyalkyl ethers and correlation with chemical structure [PDF]

, 1992
The oxidative stabilities of several perfluoropolyalkyl ethers (PFPAE) with related chemical structures were determined by thermal gravimetric analysis and correlated with their chemical structures.
Helmick, Larry S., Jones, William R., Jr.   +1 more
core   +2 more sources

Plastid genome structure and phylogenomics of the freshwater red algal order Batrachospermales (Rhodophyta)

Journal of Phycology, EarlyView.
Abstract For the freshwater red algal order Batrachospermales, the number of plastid genomes available is relatively small compared to the number of genera. Fully assembled plastid genomes can provide insights into plastid evolution and crucial data for phylogenetic reconstruction.
Roseanna M. Crowell, Nadia M. Lemes Da Silva, Monica O. Paiano, Morgan L. Vis, Orlando Necchi Jr.   +4 more
wiley   +1 more source

Developing performance indicators for the project management office depending on the project management maturity level in the company

Вестник Пермского университета: Серия Экономика, 2019
This paper defines the concept of a project management office (PMO), considers its basic functions and models. It is shown how functions of a PMO influence selection of its particular model.
Dmitry Vladimirovich Gergert, Yulia Olegovna Shturmina   +1 more
doaj   +1 more source

PENYULUHAN PMO TB PARU.pptx

, 2021
Bahan presentasi pengabdian masyarakat tentang pemberdayaan PMO pasien TB ...
Misbah, Sitti Rachmi, Atoy, Lena, Saranani, Muhaimin, Nurfantri, Nurfantri, Rini, Dewi Sartiya   +4 more
openaire   +1 more source