Results 41 to 50 of about 6,579 (136)

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull   +11 more
wiley   +1 more source

Adaptive sliding mode based active disturbance rejection control method for a direct-driven wind power conversion system

open access: yesThe Journal of Engineering, 2019
Considering the internal and external disturbances of the direct-driven wind energy conversion systems, i.e. multi-variable coupling, non-linear characteristic and modelling error, and the environmental disturbances, an adaptive sliding mode observer ...
Siyue Wang   +4 more
doaj   +1 more source

Multi‐Domain Linear Hybrid Semi‐Mechanism Modeling and Two‐Level Coordinated Control for a Cascade Dual‐Rotor Wind Turbine

open access: yesWind Energy, Volume 29, Issue 10, October 2026.
ABSTRACT For a newly emerging kind of cascade dual‐rotor wind turbine (CDR‐WT), the coordinated control of its front and rear rotor faces significant challenges. To solve this problem, a novel modeling and control design approach is presented in this paper.
Yang Hu   +3 more
wiley   +1 more source

Including Natural and Synthetic PGF2α in a 11-day FGA-Based Estrus Synchronization Protocol in Sheep: an Efficacy Comparison of Dinoprost and Cloprostenol

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
There are a variety of hormonal protocols and products on the market, but it is still unclear how they will work on specific field conditions. The efficacy of using different forms of prostaglandin F2α analogues such as dinoprost and cloprostenol in a ...
Alexandru Marius Deac   +6 more
doaj  

Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang   +12 more
wiley   +1 more source

Paternal SIRT1 Inhibition During Capacitation Imprints Histone 4 Hyperacetylation in Mouse Zygotes and Blastocysts

open access: yesReproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Sirtuin 1 (SIRT1) is a NAD+‐dependent deacetylase involved in chromatin remodelling. In this study, we evaluated whether sperm SIRT1 inhibition affects early embryonic chromatin dynamics. Sperm were treated with sirtinol during capacitation or during both capacitation and fertilization. SIRT1 inhibition increased acH4K16 in the male pronucleus
M. Iniesta‐Cuerda   +2 more
wiley   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

open access: yesAdvanced Science, Volume 13, Issue 51, 14 September 2026.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao   +13 more
wiley   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

open access: yesAdvanced Science, Volume 13, Issue 51, 14 September 2026.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li   +9 more
wiley   +1 more source

?? ??? ?????? ????????? ????????? ???? ?????? ???? ?????? ???????? ?????? PMSG ????? ????? ?????? )Coturnix japonica (

open access: yesمجلة علوم ذي قار, 2019
????? ??? ??? ? ??? ?? ???? ??????? ???????? ??? ? ???? / ????? ???????? / ???? ??? ? ??? / ????? ?????? ? ???? ?? ? ??? ????? ????? ?? ??? ?????? ????????? ????????? ???? ?????? ???? ?????? ???????? ?????? . ??????? 72 ???? ?? ???? PMSG ?????? ?????? ??
خالد جلاب كريدي الصالحي
doaj  

Single‐cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development

open access: yesClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Mature oocytes were subjected to cryopreservation followed by intracytoplasmic sperm injection (ICSI). Embryos at multiple developmental stages were collected, dissociated into single cells and processed for single‐cell library construction and bioinformatics analysis.
Yixin Ren   +14 more
wiley   +1 more source

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