Results 41 to 50 of about 6,579 (136)
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull +11 more
wiley +1 more source
Considering the internal and external disturbances of the direct-driven wind energy conversion systems, i.e. multi-variable coupling, non-linear characteristic and modelling error, and the environmental disturbances, an adaptive sliding mode observer ...
Siyue Wang +4 more
doaj +1 more source
ABSTRACT For a newly emerging kind of cascade dual‐rotor wind turbine (CDR‐WT), the coordinated control of its front and rear rotor faces significant challenges. To solve this problem, a novel modeling and control design approach is presented in this paper.
Yang Hu +3 more
wiley +1 more source
There are a variety of hormonal protocols and products on the market, but it is still unclear how they will work on specific field conditions. The efficacy of using different forms of prostaglandin F2α analogues such as dinoprost and cloprostenol in a ...
Alexandru Marius Deac +6 more
doaj
Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang +12 more
wiley +1 more source
ABSTRACT Sirtuin 1 (SIRT1) is a NAD+‐dependent deacetylase involved in chromatin remodelling. In this study, we evaluated whether sperm SIRT1 inhibition affects early embryonic chromatin dynamics. Sperm were treated with sirtinol during capacitation or during both capacitation and fertilization. SIRT1 inhibition increased acH4K16 in the male pronucleus
M. Iniesta‐Cuerda +2 more
wiley +1 more source
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao +13 more
wiley +1 more source
MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li +9 more
wiley +1 more source
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خالد جلاب كريدي الصالحي
doaj
Mature oocytes were subjected to cryopreservation followed by intracytoplasmic sperm injection (ICSI). Embryos at multiple developmental stages were collected, dissociated into single cells and processed for single‐cell library construction and bioinformatics analysis.
Yixin Ren +14 more
wiley +1 more source

