Results 271 to 280 of about 133,257 (324)

Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)-Loaded Layered Double Hydroxides (LDH) Nanoplatform.

Small, 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignant tumors with extremely poor prognosis due to the later stage diagnosis when surgical resection is no longer applicable.
Zhiguo Yu, Ping Hu, Yingying Xu, Qunqun Bao, Dalong Ni, Chenyang Wei, Jianlin Shi   +6 more
semanticscholar   +1 more source

Selective Single Molecule Nanopore Sensing of microRNA Using PNA Functionalized Magnetic Core-Shell Fe3O4-Au Nanoparticles.

Analytical Chemistry, 2019
Solid-state nanopores have been employed as useful tools for single molecule analysis due to their advantages of easy fabrication and controllable diameter, but selectivity is always a big concern for complicated samples.
Hao Wang, Haoran Tang, Cheng Yang, Yongxin Li   +3 more
semanticscholar   +1 more source

PNA Technology

Molecular Biotechnology, 2003
Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA and RNA (or PNA) oligomers, and they can also bind to targets in duplex ...
openaire   +5 more sources

A self-assembly study of PNA-porphyrin and PNA-BODIPY hybrids in mixed solvent systems.

Nanoscale, 2019
In this work a peptide nucleic acid (PNA) was covalently connected with two different chromophores, namely porphyrin and boron-dipyrromethene. To the best of our knowledge, this is the first example in the literature where a PNA unit is covalently linked
Emmanouil Nikoloudakis, Kostas Karikis, Jingjing Han, C. Kokotidou, Asterios Charisiadis, Fotios Folias, A. Douvas, A. Mitraki, Georgios Charalambidis, Xuehai Yan, A. Coutsolelos   +10 more
semanticscholar   +1 more source

Induced Chirality in PNA-PNA Duplexes

Journal of the American Chemical Society, 1995
Complementary peptide nucleic acids (PNA) form Watson-Crick base-paired helical duplexes. The preferred helicity of such a duplex is determined by a chiral amino acid attached to the C-terminus. We here show that the induced helicity, as measured by circular dichroism (CD), is drastically dependent on the nucleobase sequence proximal to the chiral ...
Wittung, P., Eriksson, Magdalena, Lyng, R., Nielsen, Peter Eigil, Norden, Bengt   +4 more
openaire   +1 more source

Pyrrolidine PNA:  A Novel Conformationally Restricted PNA Analogue

Organic Letters, 2000
[reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.
PUESCHL A., NIELSEN P. E., TEDESCHI, Tullia   +2 more
openaire   +2 more sources

Thermodynamic Studies on PNA and PNA/DNA Dendrimer Formation

Nucleosides, Nucleotides & Nucleic Acids, 2007
In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system formed by an autoassembling PNA tridendron (A) and a PNA/DNA bimolecular system based on a PNA ...
Maria Moccia, MUSUMECI, DOMENICA, Margherita Valente, Giovanni N. Roviello, Roberto Sapio, PEDONE, CARLO, Enrico M. Bucci   +6 more
openaire   +8 more sources

Solid-Phase Synthesis of Cyclic PNA and PNA−DNA Chimeras

Organic Letters, 2006
[structure: see text] A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide ...
L. MOGGIO, DE NAPOLI, LORENZO, B. DI BLASIO, DI FABIO, GIOVANNI, J. DONOFRIO, MONTESARCHIO, DANIELA, A. MESSERE   +6 more
openaire   +5 more sources

Density-functional calculations on DNA–DNA, PNA–DNA and PNA–PNA double strands

Chemical Physics Letters, 2006
Abstract Electronic properties of hybridized B-form DNA–DNA, PNA–DNA and PNA–PNA double strands with common base sequences were theoretically investigated by molecular orbital calculations based on the density functional theory. The computed hybridization energy in PNA–DNA is greater by about 5 kcal/mol than that in the DNA–DNA double strand.
Takayuki Natsume, Yasuyuki Ishikawa, Ken-ichi Dedachi, Noriyuki Kurita   +3 more
openaire   +1 more source

PNA for rapid microbiology

Journal of Microbiological Methods, 2002
The acceptance of rRNA sequence diversity as a criterion for phylogenetic discrimination heralds the transition from microbiological identification methods based on phenotypic markers to assays employing molecular techniques. Robust amplification assays and sensitive direct detection methods are rapidly becoming the standard protocols of microbiology ...
Henrik, Stender, Mark, Fiandaca, Jens J, Hyldig-Nielsen, James, Coull   +3 more
openaire   +2 more sources