Results 281 to 290 of about 133,257 (324)

Synthetic Strategies for Obtaining PNA and PNA Conjugates

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Alessandra Romanelli, Michele Saviano, Carlo Pedone   +2 more
openaire   +1 more source

Synthesis of Pyrrolidinone PNA:  A Novel Conformationally Restricted PNA Analogue

The Journal of Organic Chemistry, 2001
To preorganize PNA for duplex formation, a new cyclic pyrrolidinone PNA analogue has been designed. In this analogue the aminoethylglycine backbone and the methylenecarbonyl linker are connected, introducing two chiral centers compared to PNA. The four stereoisomers of the adenine analogue were synthesized, and the hybridization properties of PNA ...
Püschl, Ask, Boesen, Thomas, Zuccarello, Guido, Dahl, Otto, Pitsch, Stefan, Nielsen, Peter Eigil   +5 more
openaire   +2 more sources

PNA-Guided Peptide Engineering of Aptamer Sensor for Protease-Unlocked Molecular Imaging.

Angewandte Chemie, 2021
Zhichu Xiang, Jian Zhao, Deyu Yi, Zhenghan Di, Lele Li   +4 more
semanticscholar   +1 more source

Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA)

Chem. Commun., 2003
New PNA analogues derived from aminoethylpyrrolidin-5-one backbone show stabilization of aepone-PNA:DNA hybrids and destabilization of the corresponding RNA hybrids compared to unmodified PNA.
Nagendra K, Sharma, Krishna N, Ganesh
openaire   +2 more sources

Synthesis of PNA-Peptide Conjugates

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Awasthi, Satish Kumar, Nielsen, Peter E.
openaire   +3 more sources

CONSTRAINED FLEXIBILITY IN PNA: DNA BINDING STUDIES WITH BRIDGED AMINOPROPYLGLYCYL PNA

Nucleosides, Nucleotides and Nucleic Acids, 2001
Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six membered cyclic PNA monomer, aminopipecolyl PNA (pipPNA) is reported. Incorporation of pipPNA into PNA oligomers and comparative binding with target DNA sequences is studied.
P S, Lonkar, V A, Kumar, K N, Ganesh
openaire   +2 more sources

Thermal melting studies with PNA and PNA-DNA chimera

Tetrahedron Letters, 1999
Abstract We have performed thermal melting studies toward developing an empirical formula for PNA-DNA duplexes. Our results indicate the identity and sequence of the junction between the phosphodiester and 2-aminoethylglycine backbones are critical to the overall stability of the duplex and an important design consideration.
Robert G. Kuimelis, Alexander C. van der Laan, Ravi Vinayak   +2 more
openaire   +1 more source

Morpholinos and PNAs compared

Letters in Peptide Science, 2003
This chapter will compare and contrast the properties and applications of two leading antisense molecules, Peptide Nucleic Acids (PNAs)1,2 and Morpholinos3,4. Where appropriate, I discuss the compelling advantages which these two advanced ‘blocker’ types provide relative to ‘modifier’ types of antisense molecules.
openaire   +1 more source

Observation of a PNA−PNA−PNA Triplex

Journal of the American Chemical Society, 1997
Pernilla Wittung, Peter Nielsen, Bengt Nordén   +2 more
openaire   +1 more source

Highly efficient degradation of metronidazole drug using CaFe2O4/PNA nanohybrids as metal-organic catalysts under microwave irradiation

Environmental science and pollution research international, 2020
Jannatun Zia, Shahzada Misbah Farhat, E. Aazam, U. Riaz   +3 more
semanticscholar   +1 more source