Results 51 to 60 of about 1,316 (181)

Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter

JCI Insight, 2023
We examine whether calcineurin or protein phosphatase 2B (PP2B) regulates the basolateral inwardly rectifying potassium channel Kir4.1/Kir5.1 in the distal convoluted tubule (DCT). Application of tacrolimus (FK506) or cyclosporine A (CsA) increased whole-
Dan-Dan Zhang, Xin-Peng Duan, Kerim Mutig, Franziska Rausch, Yu Xiao, Jun-Ya Zheng, Dao-Hong Lin, Wen-Hui Wang   +7 more
doaj   +1 more source

Active Sonar Target Classification with Power-Normalized Cepstral Coefficients and Convolutional Neural Network

Applied Sciences, 2020
Detection and classification of unidentified underwater targets maneuvering in complex underwater environments are critical for active sonar systems.
Seungwoo Lee, Iksu Seo, Jongwon Seok, Yunsu Kim, Dong Seog Han   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, Volume 600, Issue 11, Page 1589-1604, June 2026.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Plan Nacional de Control de Cáncer en Argentina: Planificación y Puesta en Marcha [PDF]

Revista Argentina de Salud Pública, 2019
El cáncer corresponde a un grupo complejo de enfermedades de causas múltiples y diversas, que requiere un manejo multidisciplinario, interinstitucional y multisectorial.
Julia Ismael, Verónica Pesce, Celeste Díaz, Florencia Moreno, Agustín Oliveto, Nicolás Davidowicz, Lina Núñez, Mónica Confalone Gregorián   +7 more
doaj  

Structural basis for dimerization, catalytic regulation, and substrate selectivity of the chloroplast S9D CGEP protease in Arabidopsis thaliana

Protein Science, Volume 35, Issue 6, June 2026.
Abstract S9 proteases are widely distributed across the tree‐of‐life and play essential roles in protein processing. However, the structural and mechanistic basis for protease activity in the S9D subfamily, restricted to photosynthetic eukaryotes (e.g., plants), cyanobacteria, proteobacteria and flavobacteria, is unknown. Here, we report the first high‐
Jacqueline J. Ehrlich, Pratyush Routray, Louis Enns, Klaas J. van Wijk, Toshimitsu Kawate   +4 more
wiley   +1 more source

A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT

Health Technology Assessment, 2021
Background: Tranexamic acid reduces blood loss in surgery and the risk of death in trauma patients. Meta-analyses of small trials suggest that tranexamic acid decreases the number of deaths from gastrointestinal bleeding, but these meta-analyses are ...
Ian Roberts, Haleema Shakur-Still, Adefemi Afolabi, Adegboyega Akere, Monica Arribas, Emma Austin, Kiran Bal, Nuha Bazeer, Danielle Beaumont, Amy Brenner, Laura Carrington, Rizwana Chaudhri, Timothy Coats, Ian Gilmore, Kenneth Halligan, Irshad Hussain, Vipul Jairath, Kiran Javaid, Aasia Kayani, Ton Lisman, Raoul Mansukhani, Alec Miners, Muttiullah Mutti, Muhammad Arif Nadeem, Richard Pollok, Danielle Prowse, Jonathan Simmons, Simon Stanworth, Andrew Veitch, Jack Williams   +29 more
doaj   +1 more source

A Review on Explainable, Federated Multimodal AI for Heart Disease Detection Using ECG, Cardiac Imaging, and Electronic Health Records

Engineering Reports, Volume 8, Issue 4, April 2026.
Heart disease remains one of the most critical health challenges globally, accounting for a substantial number of deaths each year. With ML, DL, and FL coming into existence, early diagnosis of heart disease through ECG, Cardiac Imaging, and EHRs became increasingly feasible.
P. Murali, S. Meenatchi
wiley   +1 more source

Capturing Grasslands in Nationally Determined Contributions and Integrated Assessment Models: Review and Perspective

Earth's Future, Volume 14, Issue 3, March 2026.
Abstract Grasslands support the majority of global livestock production systems while providing vital ecosystem services. Expansion of the livestock sector over recent decades has however placed enormous pressure on grasslands, with increasing greenhouse gas emissions that challenge the aspirations of climate mitigation.
Chao Wang, Hao Zhao, Petr Havlík, Philippe Ciais, Yue Shi, Wenjuan Sun, Matthew T. Harrison, Ke Liu, Stefan Frank, Mario Herrero, Pete Smith, Jinfeng Chang   +11 more
wiley   +1 more source

Breaking barriers: transitioning from X‐ray crystallography to cryo‐EM for structural studies

Acta Crystallographica Section D, Volume 82, Issue 3, Page 253-273, March 2026.
This article describes the transition of the Glass laboratory from X‐ray crystallography to single‐particle cryo‐electron microscopy (cryo‐EM) for structural studies of ATAD2B, a large AAA+ ATPase‐ and bromodomain‐containing protein involved in chromatin regulation.
Hassan Zafar, Kiera L. Malone, Ajit K. Singh, Michael A. Cianfrocco, Karen C. Glass   +4 more
wiley   +1 more source

Power Wavelet Cepstral Coefficients (PWCC): An Accurate Auditory Model-Based Feature Extraction Method for Robust Speaker Recognition

IEEE Access
Human capability for Speaker Recognition (SR) exceeds recent machine learning approaches, even in noisy environments. To bridge this gap, researchers investigate the human auditory system to support machine learning algorithm performance.
Youssef Zouhir, Mohamed Zarka, Kais Ouni, Lilia El Amraoui   +3 more
doaj   +1 more source