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Models of pneumococcal disease
Drug Discovery Today: Disease Models, 2006Streptococcus pneumoniae is a leading cause of invasive Gram-positive disease. Infection progresses from the nasopharynx to otitis, pneumonia, bacteremia, sepsis and meningitis. Steadily increasing multidrug resistance has forced testing of new antibiotics and vaccines, as well as new adjunctive therapies based on insights into pathogenesis.
Elaine Tuomanen, Carlos J. Orihuela
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Invasive Pneumococcal and Meningococcal Disease
Infectious Disease Clinics of North America, 2019This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again.
Deirdre B. Fitzgerald, Grant W. Waterer
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The future of pneumococcal disease prevention
Vaccine, 2011Pneumococcal disease (PD) is the leading cause of vaccine preventable deaths in children
Gail L. Rodgers +2 more
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Prevention and management of pneumococcal disease
Nursing Standard, 2001Pneumococcal pneumonia is associated with high mortality in immunocompromised and older people. The authors discuss the role nurses have in increasing awareness of vaccination and use of preventive interventions to target at-risk patients.
Laila King, Jackie Burns
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The History of Pneumococcal Disease [PDF]
, 2014 This chapter reviews some of the major events in the history of Streptococcus pneumoniae—events that have led to our modern understanding of the pathogenesis, diagnosis, treatment, and prevention of pneumococcal disease. Manifestations of primary infection involved the respiratory tract, including pneumonia, acute purulent tracheobronchitis, otitis ...
Barry M. Gray, Daniel M. Musher
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The Prevention of Pneumococcal Disease in Children
New England Journal of Medicine, 2001Streptococcus pneumoniae accounts for half of all cases of acute otitis media, and it remains a major cause of illness and death in children. The strategies for prevention now include the use of a conjugate vaccine to induce immunity in infants, who are the group at highest risk.
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Impact of pneumococcal vaccines on invasive pneumococcal disease in Taiwan
European Journal of Clinical Microbiology & Infectious Diseases, 2010In Taiwan, the 23-valent pneumococcal polysaccharide vaccine (PPV23) and the 7-valent pneumococcal conjugate vaccine (PCV7) have been available since January 2001 and October 2005, respectively. A hospital-based surveillance of invasive pneumococcal disease (IPD) in a medical center was conducted from 2000 to 2008 to evaluate the epidemiologic changes ...
Che-Kim Tan +7 more
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Strategies for the control of pneumococcal diseases
Vaccine, 1999Streptococcus pneumoniae (pneumococcus) is a Gram-positive, encapsulated bacteria that is a major cause of human disease in people of all ages. It is the most important cause of bacterial pneumonia in infancy, childhood and adult life, and the most important cause of meningitis in all age groups except children of 3 months to 2 years in whom ...
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Epidemiology of Pneumococcal Disease
2014This chapter focuses on the epidemiology of pneumococcal disease in terms of pathogen characteristics and host risk factors. The clinical manifestations of Streptococcus pneumoniae infection are protean but can be classified into two major categories: invasive infections, where the organism is isolated from a normally sterile body site, such as the ...
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Smoking and Pneumococcal Disease
New England Journal of Medicine, 2000Donald E. Craven, Catherine A. Fleming
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