Results 81 to 90 of about 9,172,807 (336)

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Effectiveness and impact of the 10-valent pneumococcal conjugate vaccine, PHiD-CV: review of clinical trials and post-marketing experience

Expert Review of Vaccines, 2018
Introduction: Pneumococcal diseases (including septicemia, meningitis, pneumonia, and upper respiratory infections) constitute a major public health problem.
Tomas Mrkvan, Stephen I. Pelton, Javier Ruiz-Guiñazú, Arto A. Palmu, Dorota Borys   +4 more
doaj   +1 more source

Nasopharyngeal bacterial load as a marker for rapid and easy diagnosis of invasive pneumococcal disease in children from Mozambique.

PLoS ONE, 2017
BackgroundCurrent diagnostic methods for detection of Streptococcus pneumoniae in children with suspected invasive pneumococcal disease have limitations of accuracy, timeliness, and patient convenience.
Pedro Brotons, Quique Bassat, Miguel Lanaspa, Desiree Henares, Amaresh Perez-Arguello, Lola Madrid, Reyes Balcells, Sozinho Acacio, Maria Andres-Franch, Maria Angeles Marcos, Ana Valero-Rello, Carmen Muñoz-Almagro   +11 more
doaj   +1 more source

Invasive bacterial infections in Gambians with sickle cell anaemia in an era of widespread Pneumococcal and Haemophilus influenzae type B vaccination [PDF]

, 2016
Background: There is relatively little data on the aetiology of bacterial infections in patients with sickle cell anaemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and ...
Anderson, ST, Bah, G, Cunnington, A, Darboe, S, Lawal, B, Soothill, G   +5 more
core   +1 more source

Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine.

Journal of Infectious Diseases, 2010
BACKGROUND Changes in invasive pneumococcal disease (IPD) incidence were evaluated after 7 years of 7-valent pneumococcal conjugate vaccine (PCV7) use in US children.
T. Pilishvili, C. Lexau, M. Farley, J. Hadler, L. Harrison, N. Bennett, A. Reingold, A. Thomas, W. Schaffner, A. Craig, Philip J. Smith, B. Beall, C. Whitney, M. Moore   +13 more
semanticscholar   +1 more source

Pre‐Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

Aging Cell, EarlyView.
Pre‐vaccination immune profiles and a novel biomarker, immune entropy, are associated with responsiveness to influenza, pneumococcal, and SARS‐CoV‐2 vaccines, independent of age, sex, and CMV serostatus, and also correlate with inflammaging‐related serum proteins, supporting their potential as indicators of immunosenescence validated across diverse ...
Alper Cevirgel, Marieke van der Heiden, Sudarshan A. Shetty, Markus Viljanen, Martijn Vos, Elske Bijvank, Yannick van Sleen, Celine Imhof, Joeri A. J. Rolwes, Leonard Daniël Samson, Lisa Beckers, Nynke Rots, Josine van Beek, Anne‐Marie Buisman, Debbie van Baarle   +14 more
wiley   +1 more source

Assessing Public Health Impact of Four Pediatric Pneumococcal Conjugate Vaccination Strategies in the Netherlands

Infectious Diseases and Therapy, 2023
Introduction The 10-valent pneumococcal conjugate vaccine (PCV10, Synflorix) was introduced into the Dutch pediatric national immunization program (NIP) starting in 2011.
Michele Wilson, Cheryl McDade, Anna Trisia Beby-Heijtel, Angela Waterval-Overbeek, Vishalini Sundaram, Johnna Perdrizet   +5 more
doaj   +1 more source

Four patients with a history of acute exacerbations of COPD: implementing the CHEST/Canadian Thoracic Society guidelines for preventing exacerbations [PDF]

, 2015
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
A Singanayagam, AJ Crockett, AL Ries, AM Yohannes, C Fletcher, CE Bucknall, CM Fletcher, CP Hersh, D Brooks, DD Marciniuk, F Maltais, FA Cleutjens, G Guyatt, GJ Criner, J Chong, J Pynoos, J Strijbos, JJ Soler-Cataluna, JW Dodd, K Gruffydd-Jones, K Rockwood, K Rockwood, KH Groenewegen, L Cheyne, L Lahousse, L Puente-Maestu, LP Fried, LS Bickford, M Guell, M Stickland, M Zwerink, MM Ball, P Almagro, PG Gibson, PW Jones, S Hull, SK Park, SP Newman, T Bodenheimer, T Lee, TM Wilkinson, VS Fan, World Health Organization, Y Lacasse   +43 more
core   +1 more source

Prevention of Antibiotic-Nonsusceptible Invasive Pneumococcal Disease With the 13-Valent Pneumococcal Conjugate Vaccine.

Clinical Infectious Diseases, 2016
BACKGROUND Antibiotic-nonsusceptible invasive pneumococcal disease (IPD) decreased substantially after the US introduction of the pediatric 7-valent pneumococcal conjugate vaccine (PCV7) in 2000.
S. Tomczyk, R. Lynfield, W. Schaffner, A. Reingold, L. Miller, S. Petit, C. Holtzman, S. Zansky, A. Thomas, Joan Baumbach, L. Harrison, M. Farley, B. Beall, L. McGee, R. Gierke, Tracy Pondo, L. Kim   +16 more
semanticscholar   +1 more source

Understanding the burden of pneumococcal disease in adults [PDF]

Clinical Microbiology and Infection, 2012
Streptococcus pneumoniae causes different types of acute, invasive and non-invasive clinical infections, being the most frequently detected pathogen responsible for community-acquired pneumonia. Pneumococcal pneumonia is accompanied by bacteraemia in 10-30% of cases.
F. Blasi, M. Mantero, P.A. Santus, P. Tarsia   +3 more
openaire   +3 more sources