HIV Medicine, EarlyView.Abstract Introduction Timely diagnosis of HIV in children remains a challenge in all settings including low‐prevalence, high‐income countries (HIC). We aimed to characterize the prevalence of late diagnosis, and prior missed diagnostic opportunities among new presentations of paediatric HIV in HIC referred to an international Perinatal Virtual Clinic ...
Carolina Curto +8 more
wiley +1 more source
Four patients with a history of acute exacerbations of COPD: implementing the CHEST/Canadian Thoracic Society guidelines for preventing exacerbations [PDF]
, 2015 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
A Singanayagam +43 more
core +1 more source
Tissue Resident Memory Cells: Friend or Foe?
Immunology, EarlyView.Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude +2 more
wiley +1 more source
Vaccination against Pneumococcal Infections of High-Risk People: Pharmacoeconomic Aspects
Эпидемиология и вакцинопрофилактика, 2020 Relevance. Vaccination of people at high risk against pneumococcal infection with a 13-valent conjugate vaccine (PCV13) can significantly reduce the corresponding incidence and mortality.The aim of the work was to assess the pharmacoeconomic aspects of ...
A. V. Rudakova +2 more
doaj +1 more source
The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design
Journal of the American Geriatrics Society, EarlyView.ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui +11 more
wiley +1 more source
Therapeutic immunization with a whole cell vaccine reduces pneumococcal nasopharyngeal density, shedding, and middle ear infection in mice [PDF]
, 2023 Jayne Manning +14 more
openalex +1 more source
Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]
, 2012 Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu +64 more
core +4 more sources
Who Will Protect the Children?
Annals of the Child Neurology Society, EarlyView.
William D. Graf, Leon G. Epstein
wiley +1 more source
Successful Treatment of Severe Purpura Fulminans With Anakinra
Pediatric Dermatology, EarlyView.ABSTRACT Purpura fulminans (PF) is a rare, often fatal pediatric condition characterized by intravascular thrombosis and hemorrhagic infarction of the skin. A timely diagnosis and treatment are paramount to prevent the involvement of internal organs, causing disseminated intravascular coagulation and gangrene of the extremities.
Francesco Zulian +4 more
wiley +1 more source
Stewardship of Molecular Diagnostics in Transplant Viral Infections
Transplant Infectious Disease, EarlyView.ABSTRACT The transplant environment requires special considerations when testing for viral infections as immunosuppression results in atypical infection profiles. Microbes otherwise considered commensals or causing mild disease can lead to severe infections in transplant environments. Therefore, guidelines tend to recommend broader microbial testing in
Scott Sugden +3 more
wiley +1 more source