Results 51 to 60 of about 383,894 (265)

Predicting optimal impact interventions in the post‐HPV vaccination world

International Journal of Cancer, EarlyView.
Abstract Prophylactic vaccination is a powerful tool that changes exposure to infections and associated morbidity of preventable diseases. We discuss the impact of pneumococci and human papillomavirus (HPV) vaccination on the population biology of the two micro‐organisms and related public health effects.
Matti Lehtinen, Marc Lipsitch, Ville N. Pimenoff, Karin Sundström, Johannes Berkhof, Iacopo Baussano, Simopekka Vänskä, Joakim Dillner   +7 more
wiley   +1 more source

Detection of Pneumococcal DNA in Blood by Polymerase Chain Reaction for Diagnosing Pneumococcal Pneumonia in Young Children From Low- and Middle-Income Countries

Clinical Infectious Diseases, 2017
Background. We investigated the performance of polymerase chain reaction (PCR) on blood in the diagnosis of pneumococcal pneumonia among children from 7 low- and middle-income countries. Methods. We tested blood by PCR for the pneumococcal autolysin gene
Susan C. Morpeth, M. Deloria Knoll, J. Scott, Daniel E Park, Nora L. Watson, H. Baggett, W. A. Brooks, D. Feikin, L. Hammitt, S. Howie, K. Kotloff, O. Levine, S. Madhi, K. O'Brien, D. Thea, P. Adrian, D. Ahmed, M. Antonio, C. Bunthi, A. DeLuca, A. Driscoll, Louis Peter Githua, Melissa M Higdon, G. Kahn, A. Karani, R. Karron, G. Kwenda, Sirirat Makprasert, Razib Mazumder, D. Moore, J. Mwansa, S. Nyongesa, Christine Prosperi, S. Sow, Boubou Tamboura, T. Whistler, S. Zeger, D. Murdoch, Katherine L. Orin S. Maria Deloria Daniel R. Andrea N. Amand O’Brien Levine Knoll Feikin DeLuca Driscoll Fancou, K. O'Brien, O. Levine, M. Knoll, D. Feikin, A. DeLuca, A. Driscoll, N. Fancourt, W. Fu, L. Hammitt, Melissa M Higdon, E. Kagucia, R. Karron, Mengying Li, Daniel E Park, Christine Prosperi, Zhenke Wu, S. Zeger, Nora L. Watson, Jane Crawley, D. Murdoch, W. A. Brooks, H. Endtz, K. Zaman, D. Goswami, L. Hossain, Y. Jahan, H. Ashraf, S. Howie, B. Ebruke, M. Antonio, J. McLellan, E. Machuka, Arifin Shamsul, Syed M. A. Zaman, G. Mackenzie, J. Scott, J. Awori, Susan C. Morpeth, A. Kamau, S. Kazungu, M. Ominde, K. Kotloff, Milagritos D. Tapia, S. Sow, M. Sylla, Boubou Tamboura, U. Onwuchekwa, N. Kourouma, A. Touré, S. Madhi, D. Moore, P. Adrian, V. Baillie, Locadiah Kuwanda, Azwifarwi Mudau, M. Groome, N. Mahomed, H. Baggett, S. Thamthitiwat, S. Maloney, C. Bunthi, J. Rhodes, Pongpun Sawatwong, P. Akarasewi, D. Thea, L. Mwananyanda, J. Chipeta, P. Seidenberg, J. Mwansa, Somwe Wa Somwe, G. Kwenda, T. Anderson, Joanne L. Mitchell   +111 more
semanticscholar   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015

BMC Infectious Diseases
Background To estimate the burden of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media before and after inclusion of the 13-valent pneumococcal vaccine (PCV13) into Taiwan’s Childhood Immunization Program in ...
Ting-An Yen, Jhong-Lin Wu, Chi-Chuan Wang, Ling-Ya Huang, See-Hwee Yeo, Dony Patel, Cindy Thiow Koon Lim, Hung-Wei Lin, Eriko Yamada, Isaya Sukarom   +9 more
doaj   +1 more source

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

Gut, 2015
Objective Pneumonia accounts for more deaths than any other infectious disease worldwide. The intestinal microbiota supports local mucosal immunity and is increasingly recognised as an important modulator of the systemic immune system.
Tim J. Schuijt, J. M. Lankelma, B. Scicluna, Felipe de Sousa e Melo, J. Roelofs, J. D. D. Boer, A. Hoogendijk, R. D. Beer, A. Vos, C. Belzer, W. M. D. Vos, T. Poll, W. Wiersinga, Dr W Joost Wiersinga   +13 more
semanticscholar   +1 more source

Late diagnosis of paediatric HIV infection in high‐income countries: Lessons from the HIV Perinatal Virtual Clinic

HIV Medicine, EarlyView.
Abstract Introduction Timely diagnosis of HIV in children remains a challenge in all settings including low‐prevalence, high‐income countries (HIC). We aimed to characterize the prevalence of late diagnosis, and prior missed diagnostic opportunities among new presentations of paediatric HIV in HIC referred to an international Perinatal Virtual Clinic ...
Carolina Curto, M. Tritzali, A. Bamford, A. C. Bailey, E. G. H. Lyall, N. E. Mackie, N. Tickner, C. Foster, on behalf of the PVC   +8 more
wiley   +1 more source

A Mathematical Model of Treatment and Vaccination Interventions of Pneumococcal Pneumonia Infection Dynamics

Journal of Applied Mathematics, 2018
Streptococcus pneumoniae is one of the leading causes of serious morbidity and mortality worldwide, especially in young children and the elderly. In this study, a model of the spread and control of bacterial pneumonia under public health interventions ...
Mohammed Kizito, J. Tumwiine
semanticscholar   +1 more source

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada

Canadian Respiratory Journal, 2016
Background. Routine vaccination against Streptococcus pneumoniae is recommended in Canada for infants, the elderly, and individuals with chronic comorbidity.
Shelly A. McNeil, Nawab Qizilbash, Jian Ye, Sharon Gray, Giovanni Zanotti, Samantha Munson, Nathalie Dartois, Craig Laferriere   +7 more
doaj   +1 more source

Serotype Replacement in Adult Pneumococcal Pneumonia after the Introduction of Seven-Valent Pneumococcal Conjugate Vaccines for Children in Japan: a Systematic Literature Review and Pooled Data Analysis.

Japanese journal of infectious diseases (Print), 2017
Streptococcus pneumoniae is the major causative agent for adult pneumonia. Following the introduction of pneumococcal conjugate vaccines (PCV) for children, serotype replacement has been reported in adult invasive pneumococcal diseases but has not been ...
S. Katoh, Motoi Suzuki, K. Ariyoshi, K. Morimoto   +3 more
semanticscholar   +1 more source