Results 91 to 100 of about 659,528 (297)

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Impact and effectiveness of 13-valent pneumococcal conjugate vaccine on population incidence of vaccine and non-vaccine serotype invasive pneumococcal disease in Blantyre, Malawi, 2006–18: prospective observational time-series and case-control studies

The Lancet Global Health, 2021
Summary: Background: The population impact of pneumococcal conjugate vaccines (PCVs) depends on direct and indirect protection. Following Malawi's introduction of the 13-valent PCV (PCV13) in 2011, we examined its impact on vaccine and non-vaccine ...
Naor Bar-Zeev, PhD, Todd D Swarthout, MSc, Dean B Everett, ProfPhD, Maaike Alaerts, PhD, Jacquline Msefula, BSc, Comfort Brown, Dipl, Sithembile Bilima, BSc, Jane Mallewa, MD, Carina King, PhD, Anne von Gottberg, ProfPhD, Jennifer R Verani, MD, Cynthia G Whitney, MD, Charles Mwansambo, FRCPCH, Stephen B Gordon, ProfPhD, Nigel A Cunliffe, ProfPhD, Neil French, ProfPhD, Robert S Heyderman, ProfPhD   +16 more
doaj  

Shingles & Pneumococcal Vaccines: Recommendations for Older Adults [PDF]

, 2018
As the immune system tends to weaken over time, patients aged 50+ begin having increased risk for certain potentially preventable diseases, especially shingles and pneumonia.
Flinn, Benjamin
core   +1 more source

Comparison of the Impact of Pneumococcal Conjugate Vaccine 10 or Pneumococcal Conjugate Vaccine 13 on Invasive Pneumococcal Disease in Equivalent Populations

Clinical Infectious Diseases, 2017
Background Pneumococccal conjugated pneumococcal vaccine (PCV10) and pneumococcal conjugate vaccine 13 (PCV13), are used in childhood immunization programs worldwide, but direct comparisons of impacts against invasive pneumococcal disease (IPD) in ...
P. Nauclér, I. Galanis, E. Morfeldt, J. Darenberg, Å. Örtqvist, B. Henriques-Normark   +5 more
semanticscholar   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

A Review of Pneumococcal Vaccines: Current Polysaccharide Vaccine Recommendations and Future Protein Antigens.

The Journal of Pediatric Pharmacology and Therapeutics, 2016
This review describes development of currently available pneumococcal vaccines, provides summary tables of current pneumococcal vaccine recommendations in children and adults, and describes new potential vaccine antigens in the pipeline.
Calvin C. Daniels, P. D. Rogers, Chasity M Shelton   +2 more
semanticscholar   +1 more source

Systemic treatment of immune checkpoint inhibitor‐induced psoriasis: Inference‐based guidance

Journal of the European Academy of Dermatology and Venereology, EarlyView.
When managing psoriasis, induced or exacerbated by ICI therapy for cancer, there are concerns regarding immunosuppression from systemic agents for the treatment of psoriasis and the potential impact on ICI efficacy. No direct, high‐level evidence exists to address these concerns.
Kim A. Papp, Luis Puig, Jennifer Beecker, Vinod Chandran, Joël Claveau, Javier Cortés, Jan Dutz, Noah I. Hornick, Rosalyn A. Juergens, Barbara Melosky, Anisha B. Patel, Maxwell B. Sauder, Sandeep Sehdev, Vincent Sibaud, Stephanie L. Snow   +14 more
wiley   +1 more source

Evaluation of differences in S. pneumoniae colonization among children with and without clinically diagnosed asthma/wheeze [PDF]

, 2017
Streptococcus pneumoniae colonization is the nasopharynx is common in young children. Colonization of S. pneumoniae is a necessary precursor for invasive pneumococcal disease (IPD), which is a major cause of morbidity and mortality among children less ...
Alishahi, Musheng
core  

Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types [PDF]

, 2011
We describe associations between death from invasive pneumococcal disease (IPD) and particular serogroups and sequence types (STs) determined by multilocus sequence typing (MLST) using data from Scotland.
Andrew Smith, Aspa, Austrian, Avery, Blake, Cecil, Chris Robertson, David Greenhalgh, Diggle, Donald Inverarity, Giles F. S. Edwards, Guimbao Bescós, Huss, Inostroza, Jim McMenamin, Johanna M. C. Jefferies, Karen Lamb, Kendrick, Lamb, Martin, Mathew Diggle, Shapiro, Stuart C. Clarke, Tim J. Mitchell, Weiss   +24 more
core   +3 more sources

Respiratory Syncytial Virus (RSV)‐Related Hospitalization and Increased Rate of Cardiovascular Events in Older Adults

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Recent studies suggest that respiratory syncytial virus (RSV) can cause severe illness in terms of in‐hospital outcomes and mortality. The degree to which RSV hospitalization is associated with cardiovascular outcomes, particularly those known to occur following acute respiratory infections, is poorly described. Methods We conducted
Chris P. Verschoor, Joshua O. Cerasuolo, Joseph M. Caswell, Mark Tatangelo, Atilio Costa‐Vitali, David W. Savage, Jeffrey C. Kwong   +6 more
wiley   +1 more source