Results 71 to 80 of about 659,528 (297)

Novel Protein-Based Pneumococcal Vaccines: Assessing the Use of Distinct Protein Fragments Instead of Full-Length Proteins as Vaccine Antigens

Vaccines, 2019
Non-serotype-specific protein-based pneumococcal vaccines have received extensive research focus due to the limitations of polysaccharide-based vaccines.
Theano Lagousi, Paraskevi Basdeki, J. Routsias, V. Spoulou   +3 more
semanticscholar   +1 more source

Otitis Media Trial Publication After ClinicalTrials.gov Registration

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the proportion of completed otitis media (OM) clinical trials registered on ClinicalTrials.gov and identify factors associated with nonpublication. Study Design Cross‐sectional observational study. Setting ClinicalTrials.gov registry and peer‐reviewed literature databases.
Michael Oca, Suraj M. Rajan, Z. Jason Qian   +2 more
wiley   +1 more source

From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood [version 1; referees: 3 approved] [PDF]

, 2017
In the past century, advances in antibiotics and vaccination have dramatically altered the incidence and clinical outcomes of bacterial meningitis. We review the shifting epidemiology of meningitis in children, including after the implementation of ...
Janowski, Andrew B, Newland, Jason G
core   +3 more sources

Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults.

New England Journal of Medicine, 2015
BACKGROUND Pneumococcal polysaccharide conjugate vaccines prevent pneumococcal disease in infants, but their efficacy against pneumococcal community-acquired pneumonia in adults 65 years of age or older is unknown. METHODS In a randomized, double-blind,
M. Bonten, S. Huijts, M. Bolkenbaas, Chris Webber, S. Patterson, S. Gault, C. H. van Werkhoven, A. V. van Deursen, E. Sanders, T. Verheij, Michael Patton, A. McDonough, A. Moradoghli-Haftvani, Helen M Smith, Tracey Mellelieu, M. Pride, Graham R. Crowther, B. Schmoele-Thoma, D. Scott, K. Jansen, R. Lobatto, B. Oosterman, Nils Visser, E. Caspers, Andre J. Smorenburg, E. Emini, W. Gruber, D. Grobbee   +27 more
semanticscholar   +1 more source

Pre‐Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

Aging Cell, EarlyView.
Pre‐vaccination immune profiles and a novel biomarker, immune entropy, are associated with responsiveness to influenza, pneumococcal, and SARS‐CoV‐2 vaccines, independent of age, sex, and CMV serostatus, and also correlate with inflammaging‐related serum proteins, supporting their potential as indicators of immunosenescence validated across diverse ...
Alper Cevirgel, Marieke van der Heiden, Sudarshan A. Shetty, Markus Viljanen, Martijn Vos, Elske Bijvank, Yannick van Sleen, Celine Imhof, Joeri A. J. Rolwes, Leonard Daniël Samson, Lisa Beckers, Nynke Rots, Josine van Beek, Anne‐Marie Buisman, Debbie van Baarle   +14 more
wiley   +1 more source

Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: A longitudinal household study [PDF]

, 2005
Background. Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S.
Andrews, N, Ashton, L, Edmunds, J, Gay, N, George, R, Goldblatt, D, Hussain, M, Kayhty, H, Melegaro, A, Miller, E, Pebody, R, Soininen, A, Virta, C   +12 more
core  

The potential role of pneumococcal conjugate vaccine in reducing acute respiratory inflammation in community-acquired pneumococcal pneumonia

Journal of Biomedical Science, 2020
Background Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of ...
Ching-Fen Shen, Shih-Min Wang, Hsin Chi, Yi-Chuan Huang, Li-Min Huang, Yhu-Chering Huang, Hsiao-Chuan Lin, Yu-Huai Ho, Chao A. Hsiung, Ching-Chuan Liu, Taiwan Pediatric Infectious Disease Alliance   +10 more
doaj   +1 more source

Molecular epidemiology of pneumococci obtained from Gambian children aged 2-29 months with invasive pneumococcal disease during a trial of a 9-valent pneumococcal conjugate vaccine. [PDF]

, 2008
BACKGROUND: The study describes the molecular epidemiology of Streptococcus pneumoniae causing invasive disease in Gambian children METHODS: One hundred and thirty-two S. pneumoniae isolates were recovered from children aged 2-29 months during the course
Adegbola, Richard A, Antonio, Martin, Awine, Tim, Biney, Ekow, Cutts, Felicity, Dada-Adegbola, Hannah, Enwere, Godwin, Greenwood, Brian M, O'Callaghan, John, Okoko, Brown, Oluwalana, Claire, Pfluger, Valentin, Pluschke, Gerd, Vaughan, Adeola, Zaman, Syed Ma   +14 more
core   +2 more sources

Pneumococcal carriage in children and their household contacts six years after introduction of the 13-valent pneumococcal conjugate vaccine in England

PLoS ONE, 2018
Background In April 2010, 13-valent pneumococcal conjugate vaccine (PCV13) replaced PCV7 in the infant immunisation schedule in England and Wales. Despite limited serotype replacement in invasive pneumococcal disease (IPD) during the first four post ...
J. Southern, N. Andrews, P. Sandu, C. Sheppard, P. Waight, N. Fry, A. V. van Hoek, E. Miller   +7 more
semanticscholar   +1 more source

Late infections after high‐dose therapy and autologous stem cell transplantation for lymphoma: A Danish population‐based study

British Journal of Haematology, EarlyView.
Summary Infectious complications after high‐dose therapy and autologous stem cell transplantation (HDT‐ASCT) for lymphoma are the leading cause of late non‐relapse mortality. Characterizing the risk of infectious complications over time is important for rational follow‐up and because alternatives to HDT‐ASCT exist for some patients.
Freja Tang Severinsen, Mikkel Runason Simonsen, Eva Futtrup Maksten, Lasse Hjort Jakobsen, Rasmus Kuhr Jensen, Kirstine Kobberøe Søgaard, Paw Jensen, Peter de Nully Brown, Judit Mészáros Jørgensen, Thomas Stauffer Larsen, Christian Bjørn Poulsen, Tarec Christoffer El‐Galaly   +11 more
wiley   +1 more source