Results 91 to 100 of about 633,971 (314)
Rheumatology &Autoimmunity, EarlyView.Recent multi‐omics studies have demonstrated that belimumab specifically targets naïve B cells and a subset of memory B cells. This observation is consistent with belimumab's established efficacy and safety profile. Abstract Belimumab is an antibody targeting the cytokine B‐cell activating factor (BAFF), which is crucial for B cell differentiation, and
Keishi Fujio +5 more
wiley +1 more source
Pneumococcal capsular polysaccharide immunity in the elderly. [PDF]
, 2017 Immunity against pneumococcal infections is impaired in older people, and current vaccines are poorly protective against pneumococcal disease in this population.
Boyd AR +5 more
core +1 more source
Theory and strategy for Pneumococcal vaccines in the elderly
Human Vaccines & Immunotherapeutics, 2015 Pneumonia is the fourth-leading cause of death globally, and Streptococcus pneumoniae is the most important causative pathogen. Because the incidence of pneumococcal diseases is likely to increase with the aging society, we should determine an optimal ...
H. Namkoong +12 more
semanticscholar +1 more source
Polysaccharide pneumococcal vaccines
BMJ, 2002 Infection with Streptococcus pneumoniae (pneumococcus) is a leading cause of illness in young children and of illness and death in elderly people and people with immune deficiencies and chronic illness. Pneumococcus causes a spectrum of disease: infections of the upper respiratory tract, otitis media, invasive infections such as bacteraemia and ...
Vittorio Demicheli, Tom Jefferson
openaire +4 more sources
Aging Cell, EarlyView.During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu +4 more
wiley +1 more source
Zhongguo gonggong weishengObjectiveTo understand the pneumococcal vaccination status and its influencing factors among young and middle-aged populations, and provide reference for promoting pneumococcal vaccination.
Ziying CHEN +10 more
doaj +1 more source
Redefining risk categories for pneumococcal disease in adults: critical analysis of the evidence
International Journal of Infectious Diseases, 2015 Objective: To analyze the available published data (2005–2014) describing the prevalence of multimorbidity in adult patients with pneumococcal disease, with a focus on the comorbidities considered by the Advisory Committee on Immunization Practices (ACIP)
Daniel Curcio +2 more
doaj +1 more source
Vaccines, 2023 Pneumococcal disease remains one of the major causes of severe disease in both children and adults. Severe disease may be prevented by pneumococcal polysaccharide and conjugate vaccines, which currently cover more than 20 serotypes.
Kay Choong See
doaj +1 more source
The Impact of Vaccine Hesitancy on Epidemic Spreading [PDF]
arXiv, 2021 The COVID-19 pandemic has devastated the world in an unprecedented way, causing enormous loss of life. Time and again, public health authorities have urged people to become vaccinated to protect themselves and mitigate the spread of the disease. However, vaccine hesitancy has stalled vaccination levels in the United States.
arxiv
Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]
, 2012 Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A +18 more
core +2 more sources