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Pneumococcal Infections and Pneumococcal Vaccine: An Update

Infection Control, 1982
AbstractPneumococcal pneumonia continues to be an important disease in terms of prevalence, morbidity and mortality. With the discovery of penicillin and its wide clinical use, the overall mortality of pneumococcal pneumonia has been significantly reduced, but problems remain.
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Pneumococcal conjugate vaccines

Immunology Letters, 1991
We have prepared conjugates of pneumococcal type 4 polysaccharides (PS4) or oligosaccharides to tetanus toxoid using the carbodiimide method. The use of a spacer, 6-aminohexanoic acid, resulted in higher incorporation of carrier protein. Conjugates contained up to 10% free polysaccharide, but no free protein.
C C, Peeters   +6 more
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Correction: Pneumococcal Vaccine and Pneumococcal Pneumonia

Annals of Internal Medicine, 1988
Excerpt To the Editor:Sims and colleagues made the following statement in their article on pneumococcal vaccine (1): Studies of sufficient statistical power have consistently shown the efficacy of ...
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Pneumococcal vaccination of children

Seminars in Pediatric Infectious Diseases, 2002
Streptococcus pneumoniae is the most frequent cause of invasive bacterial infection in children younger than 2 years of age, reaching a peak incidence at 6 to 12 months of age. Pneumococci also cause many cases of pneumonia, sinusitis, and otitis media.
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Pneumococcal conjugate vaccine

Current Opinion in Pediatrics, 2001
Pneumococcal infections account for a significant proportion of bacterial infections in infants and children. The growing threat from pneumococci resistant to penicillin and other antimicrobials has led to increased pressure for the development of an effective vaccine.
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Pneumococcal Vaccine Efficacy

Annals of Internal Medicine, 1986
Excerpt To the editor: In the January issue, Bolan and colleagues (1) describe their analysis of the distribution of pneumococcal serotypes isolated from blood and cerebrospinal fluid of vaccinated...
M, Aloizou, S, Lomasky, P D, Lief
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Pneumococcal Vaccine: An Update

Pediatrics, 1999
* Abbreviation: HIV = : human immunodeficiency virus Streptococcus pneumoniae is the most common cause of invasive bacterial infection in children. In addition, the organism causes 30% to 50% of cases of acute otitis media; 24 million visits to pediatricians per year in the United States are referable to this diagnosis.1 It is also ...
R P, Wadwa, R D, Feigin
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Evaluation of Pneumococcal Vaccine

JAMA: The Journal of the American Medical Association, 1981
To the Editor.— Regarding the article entitled "A Cost-Benefit Analysis of Immunization of Pneumococcal Pneumonia" by Patrick and Woolley (1981; 245:473), this analysis and one published previously 1 required estimation of a number of variables, including incidence of vaccine reactions and vaccine-type Streptococcus pneumoniae infections in vaccine ...
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Pneumococcal Conjugate Vaccines

1995
The development of multivalent pneumococcal vaccines for the prevention of both systemic and noninvasive pneumococcal diseases in infants, older adults, and immunecompromised individuals has gained increasing importance over the last decade. The rising cost of medical care has renewed interest in prevention instead of cure for a disease and in many ...
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Pneumococcal Vaccine and Splenectomy

JAMA: The Journal of the American Medical Association, 1980
To the Editor.— Regarding the answer in the QUESTIONS AND ANSWERS section by Theodore H. Spaet, MD (242:1413, 1979), I want to comment on the efficacy of pneumococcal vaccine in the spleenless patients. General studies and reports pertinent to the value of the vaccine in asplenic patients have been published.
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