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Pneumococcal conjugate vaccines
Immunology Letters, 1991We have prepared conjugates of pneumococcal type 4 polysaccharides (PS4) or oligosaccharides to tetanus toxoid using the carbodiimide method. The use of a spacer, 6-aminohexanoic acid, resulted in higher incorporation of carrier protein. Conjugates contained up to 10% free polysaccharide, but no free protein.
Bart L. Haagmans +6 more
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Pneumococcal vaccines for cystic fibrosis.
Cochrane Database of Systematic Reviews, 2014BACKGROUND Invasive pneumococcal disease is associated with significant mortality and many countries have introduced routine pneumococcal vaccination into their childhood immunisation programmes. Whilst pneumococcal disease in cystic fibrosis is uncommon,
L. Burgess, K. Southern
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Pneumococcal vaccination of children
Seminars in Pediatric Infectious Diseases, 2002Streptococcus pneumoniae is the most frequent cause of invasive bacterial infection in children younger than 2 years of age, reaching a peak incidence at 6 to 12 months of age. Pneumococci also cause many cases of pneumonia, sinusitis, and otitis media.
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Pneumococcal conjugate vaccine
Current Opinion in Pediatrics, 2001Pneumococcal infections account for a significant proportion of bacterial infections in infants and children. The growing threat from pneumococci resistant to penicillin and other antimicrobials has led to increased pressure for the development of an effective vaccine.
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Evaluation of Pneumococcal Vaccine
JAMA: The Journal of the American Medical Association, 1981To the Editor.— Regarding the article entitled "A Cost-Benefit Analysis of Immunization of Pneumococcal Pneumonia" by Patrick and Woolley (1981; 245:473), this analysis and one published previously 1 required estimation of a number of variables, including incidence of vaccine reactions and vaccine-type Streptococcus pneumoniae infections in vaccine ...
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Pneumococcal Vaccine: An Update
Pediatrics, 1999* Abbreviation: HIV = : human immunodeficiency virus Streptococcus pneumoniae is the most common cause of invasive bacterial infection in children. In addition, the organism causes 30% to 50% of cases of acute otitis media; 24 million visits to pediatricians per year in the United States are referable to this diagnosis.1 It is also ...
Feigin Rd, Wadwa Rp
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Pneumococcal Infections and Pneumococcal Vaccine: An Update
Infection Control, 1982AbstractPneumococcal pneumonia continues to be an important disease in terms of prevalence, morbidity and mortality. With the discovery of penicillin and its wide clinical use, the overall mortality of pneumococcal pneumonia has been significantly reduced, but problems remain.
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Pneumococcal Vaccination in Diabetes
JAMA: The Journal of the American Medical Association, 1981To the Editor.— The COMMENTARY by James M. Moss, MD (1980;243:2301), entitled "Pneumococcus Infection in Diabetes Mellitus: Is This a Justification for Immunization?" concluded that diabetes is not a valid indication for pneumococcal vaccination because excess risk for development of the disease among diabetics has not been established. I do not think
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Correction: Pneumococcal Vaccine and Pneumococcal Pneumonia
Annals of Internal Medicine, 1988Excerpt To the Editor:Sims and colleagues made the following statement in their article on pneumococcal vaccine (1): Studies of sufficient statistical power have consistently shown the efficacy of ...
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Pneumococcal Polysaccharide Vaccines
Clinical Infectious Diseases, 1989Pneumococcal infections are major causes of morbidity and mortality in children throughout the world. For this reason and because of the increasingly frequent isolation of multiply resistant pneumococci of the serotypes most often causing infection in childhood, prophylactic immunization offers the best prospect of reducing the incidence of such ...
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