Results 21 to 30 of about 22,642 (226)

Perioperative Nivolumab in Resectable Non‐Small Cell Lung Cancer: A Subanalysis of Japanese Patients From CheckMate 77T

Cancer Science, EarlyView.
ABSTRACT In the randomized phase III CheckMate 77T study, perioperative nivolumab showed statistically significant and clinically meaningful improvement in event‐free survival (EFS) vs. placebo in patients with resectable, non‐metastatic non‐small cell lung cancer (NSCLC).
Fumihiro Tanaka, Yasutaka Watanabe, Shunichi Sugawara, Jiro Okami, Satoshi Muto, Morihito Okada, Yoshitsugu Horio, Masahiro Tsuboi, Yuki Sato, Kazuya Takamochi, Hidehito Horinouchi, Yuichi Tambo, Masahiro Seike, Kyoichi Okishio, Cinthya Coronado Erdmann, Padma Sathyanarayana, Stephanie Meadows‐Shropshire, Hiroyuki Ito   +17 more
wiley   +1 more source

A rare cause of dyspnea on exertion with a cardiopulmonary exercise stress test

Respiratory Medicine Case Reports
Informative abstract: Background: It is rare for an adult patient to be living decades after a pneumonectomy procedure. This case features complications that can arise.
Elizabeth H. Lees, Hernan Cardozo Torres, Eric S. Edell, Gustavo Cortes Puentes, Thomas A. Foley, Janani S. Reisenauer, Thomas G. Allison   +6 more
doaj   +1 more source

Nuclear factor-kappa B influences early phase of compensatory lung growth after pneumonectomy in mice

Journal of Biomedical Science, 2017
Background Compensatory lung growth (CLG) is a well-established lung regeneration model. However, the sequential mechanisms, including unknown molecular triggers or regulators, remain unclear.
Yusuke Takahashi, Noriyuki Matsutani, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara, Masafumi Kawamura   +5 more
doaj   +1 more source

Mechanopharmacology of cellular microenvironment stiffness: Therapeutic strategies for age‐related diseases

British Journal of Pharmacology, Volume 183, Issue 4, Page 945-956, February 2026.
Ageing brings about various biochemical, structural and mechanical alterations within tissues, profoundly impacting cellular behaviour and function. One of the hallmark changes observed with ageing is an increase in cellular microenvironment stiffness, a biomechanical property influenced by intrinsic factors within the cell and extrinsic factors from ...
Wang HaiYang, Cheong Dorothy Hui Juan, Lee Zhao‐Yong, Tran Thai   +3 more
wiley   +1 more source

Scintigraphic Assessment of Pulmonary Flow in Patients After Pneumonectomy

Diagnostics
Background: Pulmonary circulation typically shows flow divided between the right and left lungs, with a marked predominance of the right lung.
Bogumił Maciąg, Małgorzata Edyta Wojtyś, Arkadiusz Waloryszak, Norbert Wójcik, Jarosław Pieróg, Krzysztof Safranow, Tadeusz Sulikowski, Tomasz Grodzki, Janusz Wójcik   +8 more
doaj   +1 more source

Is the flap reinforcement of the bronchial stump really necessary to prevent bronchial fistula?

Journal of Cardiothoracic Surgery, 2020
Background/aim The development of bronchopleural fistula (BPF) remains the most severe complication of lung resection, especially after pneumonectomy.
Fatmir Caushi, Gentiana Qirjako, Ilir Skenduli, Daniela Xhemalaj, Hasan Hafizi, Silva Bala, Alban Hatibi, Arian Mezini   +7 more
doaj   +1 more source

Single‐nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC)

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Single‐nucleus RNA sequencing (snRNA‐seq) maps the cellular diversity of pulmonary sarcomatoid carcinoma (PSC) and primary pulmonary sarcomas (PPS). AT2 cells, a major source of epithelial cells in PSC, underwent malignant transformation primarily through epithelial–mesenchymal transition, suggesting AT2 cells may serve as the origin of PSC.
Jianfei Zhu, Yanlu Xiong, Shouzheng Ma, Jun Wei, Jiakuan Chen, Wenchen Wang, Qianqian Duan, Qin Zhang, Dongsheng Chen, Wanglong Deng, Tao Jiang, Jie Lei   +11 more
wiley   +1 more source

A new approach to left sleeve pneumonectomy: complete VATS left pneumonectomy followed by right thoracotomy for carinal resection and reconstruction

Surgical Case Reports, 2018
Background Left sleeve pneumonectomy is a challenging operation that requires individualized approaches. Here, we present a new minimally invasive combined thoracoscopic approach.
Toshio Fujino, Masayuki Tanahashi, Haruhiro Yukiue, Eriko Suzuki, Naoko Yoshii, Masayuki Shitara, Yasunori Kaminuma, Hiroshi Niwa   +7 more
doaj   +1 more source

Trends and Survival Outcomes of Lung Cancer Surgery in South Korea, 2015–2019

Thoracic Cancer, Volume 17, Issue 2, January 2026.
Among 36 663 Korean patients undergoing curative lung cancer resection (2015–2019), the use of segmentectomy and wedge resection increased while pneumonectomy declined. In multivariable Cox models, lobectomy was associated with the most favorable survival in patients aged 46–75 years (adjusted hazard ratio [aHR] 0.789; 95% CI 0.734–0.849), whereas ...
Chanwoo Kim, Kyoung Eun Yeob, Hee‐Sung Kim, Se Eun Park, Jae Yeon Kim, Pankaj Kumar Chaturvedi, Hee Soo Yang, So Young Kim, Jong Hyock Park, Dohun Kim   +9 more
wiley   +1 more source

A pneumonectomy model to study flow-induced pulmonary hypertension and compensatory lung growth

Cell Reports: Methods, 2023
Summary: In newborns, developmental disorders such as congenital diaphragmatic hernia (CDH) and specific types of congenital heart disease (CHD) can lead to defective alveolarization, pulmonary hypoplasia, and pulmonary arterial hypertension (PAH ...
Savas T. Tsikis, Timothy Klouda, Thomas I. Hirsch, Scott C. Fligor, Tiffany Liu, Yunhye Kim, Amy Pan, Mikayla Quigley, Paul D. Mitchell, Mark Puder, Ke Yuan   +10 more
doaj   +1 more source