Results 191 to 200 of about 8,207,451 (247)

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu   +5 more
wiley   +1 more source

Treatment Patterns and Clinical Outcomes in Children with <i>Stenotrophomonas maltophilia</i> Infections. [PDF]

open access: yesMicroorganisms
Mitchell C   +7 more
europepmc   +1 more source

New Medical Schools, Access to Physicians, and Health Outcomes: Evidence From Japan

open access: yesHealth Economics, Volume 35, Issue 11, Page 1693-1733, November 2026.
ABSTRACT We analyse the impact of the construction of medical schools and associated university hospitals in Japan during the 1970s, which was primarily driven by ‘One Prefecture, One Medical School Policy’ (OPOMS). We find that the number of physicians increased significantly in prefectures where a medical school was built, and this effect persisted ...
Kisho Hoshi
wiley   +1 more source

Surgical Removal of Residual Tumor Masses in Patients Undergoing Targeted Therapy for EGFR‐Mutated Locally Advanced or Metastatic Lung Cancer

open access: yesInternational Journal of Cancer, Volume 159, Issue 9, Page 2244-2261, 1 November 2026.
Non‐small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations often exhibit significant tumor reduction following tyrosine kinase inhibitor (TKI) therapy. Residual tumors frequently remain, however, leading to drug resistance and disease progression.
Fedor Moiseenko   +31 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan   +23 more
wiley   +1 more source

Computed tomographic characterisation and surgical management of a caudal mediastinal paraoesophageal abscess with associated pneumonia in a dog

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract An 8‐year‐old, entire, male German shorthaired pointer presented with acute respiratory distress, pyrexia and coughing following a period of boarding. Thoracic radiographs identified a caudal mediastinal mass effect with severe multilobar bronchopneumonia.
Yi Gu   +4 more
wiley   +1 more source

Fulminant brachycephalic obstructive airway syndrome in a 3‐month‐old French bulldog

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 3‐month‐old, entire, female French bulldog (6.4 kg) presented in severe respiratory distress with hyperthermia and cyanosis. Laryngeal examination revealed severe obstruction by oedematous tissue, later confirmed as bilaterally everted laryngeal saccules; the airway was stabilised by tracheal intubation.
Yasumasa Iimori   +4 more
wiley   +1 more source

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