SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
Treatment Patterns and Clinical Outcomes in Children with <i>Stenotrophomonas maltophilia</i> Infections. [PDF]
Mitchell C +7 more
europepmc +1 more source
New Medical Schools, Access to Physicians, and Health Outcomes: Evidence From Japan
ABSTRACT We analyse the impact of the construction of medical schools and associated university hospitals in Japan during the 1970s, which was primarily driven by ‘One Prefecture, One Medical School Policy’ (OPOMS). We find that the number of physicians increased significantly in prefectures where a medical school was built, and this effect persisted ...
Kisho Hoshi
wiley +1 more source
Non‐small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations often exhibit significant tumor reduction following tyrosine kinase inhibitor (TKI) therapy. Residual tumors frequently remain, however, leading to drug resistance and disease progression.
Fedor Moiseenko +31 more
wiley +1 more source
Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Adult Intensive Care Unit Patients: A Systematic Review and Meta-Analysis. [PDF]
Meremikwu K +4 more
europepmc +1 more source
Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan +23 more
wiley +1 more source
Potential protective effect of dental treatment among subgroups of critically ill ventilated patients: a retrospective survival analysis. [PDF]
Garcia FM +4 more
europepmc +1 more source
Abstract An 8‐year‐old, entire, male German shorthaired pointer presented with acute respiratory distress, pyrexia and coughing following a period of boarding. Thoracic radiographs identified a caudal mediastinal mass effect with severe multilobar bronchopneumonia.
Yi Gu +4 more
wiley +1 more source
Congenital Pulmonary Airway Malformation Presenting as Pneumothorax: Two Case Reports. [PDF]
Athman LP, Malyas H, Nkuba J, Shoo A.
europepmc +1 more source
Fulminant brachycephalic obstructive airway syndrome in a 3‐month‐old French bulldog
Abstract A 3‐month‐old, entire, female French bulldog (6.4 kg) presented in severe respiratory distress with hyperthermia and cyanosis. Laryngeal examination revealed severe obstruction by oedematous tissue, later confirmed as bilaterally everted laryngeal saccules; the airway was stabilised by tracheal intubation.
Yasumasa Iimori +4 more
wiley +1 more source

