Results 191 to 200 of about 683,865 (337)

Expanding the Tyrosine Kinase Domain of CSF1R? A Case Report From an Adult‐Onset Leukoencephalopathy

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), also termed hereditary diffuse leukoencephalopathy with spheroids‐1 (HDLS1), results from mutations in the CSF1R gene and leads to progressive leukoencephalopathy.
Piervito Lopriore   +11 more
wiley   +1 more source

Treatment‐related adverse events of antibody–drug conjugates in clinical trials: A systematic review and meta‐analysis

open access: yesCancer, Volume 129, Issue 2, Page 283-295, 15 January 2023., 2023
Abstract Background Antibody–drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance. Methods In a systematic review and meta‐analysis of data gathered from different scientific databases ...
Youwen Zhu   +3 more
wiley   +1 more source

The old man’s friend

open access: yesPneumonia, 2018
Ger T. Rijkers, Stephen I. Pelton
doaj   +1 more source

Antiviral effects and mechanism of Qi pi pill against influenza viruses

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Qi pi pill presents anti‐influenza effect and inhibits viral replication in vitro by targeting both the viral RNA replication and the release of new viral particles. Furthermore, QPP modulates the production of proinflammatory cytokines induced by influenza infection in host cells.
Chengcheng Zhang   +10 more
wiley   +1 more source

Binding Energy Partition of Promising IRAK‐4 Inhibitor (Zimlovisertib) for the Treatment of COVID‐19 Pneumonia

open access: yesChemPhysChem, Volume 23, Issue 24, December 16, 2022., 2022
The electronic energy was divided throughout the Fragment‐Based Drug Design (FBDD) process of the drug Zimlovisertib using the Interacting Quantum Atoms method. The authors could thereby establish the suitability of the chemical modifications in each step of FBDD, providing a valuable test through an FBDD process.
César A. Zapata‐Acevedo   +3 more
wiley   +1 more source

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