Results 71 to 80 of about 762,477 (313)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Microbiological etiologies of pneumonia complicating stroke: A systematic review [PDF]

, 2018
Background and Purpose—Identifying the causal pathogens of pneumonia complicating stroke is challenging, and antibiotics used are often broad spectrum, without recourse to the microbiological cause.
Kishore, Amit K., Chamorro, Angel, Smith, Craig J, Jeans, Adam R., Langhorne, Peter, Mark Woodhead, Craig J. Smith, Amit K. Kishore, Lalit Kalra, Vail, Andy, Kishore, Amit, Peter Langhorne, van de Beek, Diederik, Diederik van de Beek, Joan Montaner, Nederkoorn, Paul J, Woodhead, Mark, Christine Roffe, Nederkoorn, Paul J., Westendorp, Willeke, Andreas Meisel, Vail, Andy; id_orcid, Andy Vail, van-de-Beek, Diederik, Smith, Craig J., Roffe, Christine, Paul J. Nederkoorn, Mario Di Napoli, Willeke Westendorp, Beek, Diederik van de, Montaner, Joan, Di Napoli, Mario, Kalra, Lalit, null null, Meisel, Andreas, Di-Napoli, Mario, Adam R. Jeans, Javier Garau, Kishore, Amit K, Angel Chamorro, Smith, Craig, Garau, Javier, Jeans, Adam R   +42 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Hospital management of community-acquired pneumonia in Malta [PDF]

, 2012
Community-acquired pneumonia (CAP) remains a common diagnosis requiring hospital admission and a leading cause of death worldwide. No local guideline is currently available for the management of CAP.
Mamo, Jonathan, Micallef, Josef, Callus, Roberta, Montefort, Stephen   +3 more
core  

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

Accuracy of the recording of pneumonia events in English electronic healthcare record data in patients with chronic obstructive pulmonary disease [PDF]

Background In primary care, identifying pneumonia events in people with chronic obstructive pulmonary disease (COPD) may be challenging due to similarities in symptoms with COPD exacerbations and lack of diagnostic testing.
Kallis, Constantinos, Adamson, Alexander J, Douglas, Ian, Quint, Jennifer K, Adamson, Alex, Quint, Jennifer   +5 more
core   +1 more source

Risk factors for childhood pneumonia at Adama Hospital Medical College, Adama, Ethiopia: a case-control study

Pneumonia, 2022
Background Pneumonia is an acute respiratory infection of the lungs. A child dies of pneumonia every 39 s globally. Even though pneumonia affects children worldwide, the risk and repercussions of the disease are more prevalent in poor and middle-income ...
Tsega-Ab Abebaw, William Kiros Aregay, Mulu Tugi Ashami   +2 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Community-acquired pneumonia in the United Kingdom: a call to action

Pneumonia, 2017
Pneumococcal disease has a high burden in adults in the United Kingdom (UK); however, the total burden is underestimated, principally because most cases of community-acquired pneumonia (CAP) are non-invasive. Research into pneumonia receives poor funding
James Chalmers, James Campling, Gillian Ellsbury, Peter M. Hawkey, Harish Madhava, Mary Slack   +5 more
doaj   +1 more source

Mutational analysis of the gene start sequences of pneumonia virus of mice [PDF]

, 2007
The transcriptional start sequence of pneumonia virus of mice is more variable than that of the other pneumoviruses, with five different nine-base gene start (GS) sequences found in the PVM genome.
Easton, A. J. (Andrew J.), Dibben, Oliver   +1 more
core   +1 more source