Results 41 to 50 of about 2,523 (182)

Using embedded alginate microparticles to tune the properties of in situ forming poly(N‐isopropylacrylamide)‐graft‐chondroitin sulfate bioadhesive hydrogels for replacement and repair of the nucleus pulposus of the intervertebral disc

JOR Spine, 2021
Low back pain is a major public health issue associated with degeneration of the intervertebral disc (IVD). The early stages of degeneration are characterized by the dehydration of the central, gelatinous portion of the IVD, the nucleus pulposus (NP ...
Thomas Christiani, Karen Mys, Karl Dyer, Jennifer Kadlowec, Cristina Iftode, Andrea Jennifer Vernengo   +5 more
doaj   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system

Journal of Applied Biomaterials & Functional Materials
Numerous studies have addressed the use of vancomycin (VA) to effectively treat bacterial infections. However, VA is known to cause side effects when administered intravenously.
Liang Lei, Shanlong Li, Xuefeng Kang, Jian Shang   +3 more
doaj   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, Volume 36, Issue 63, 6 August 2026.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Thermoresponsive Cationic Polymers: PFAS Binding Performance under Variable pH, Temperature and Comonomer Composition

Gels, 2022
The versatility and unique qualities of thermoresponsive polymeric systems have led to the application of these materials in a multitude of fields. One such field that can significantly benefit from the use of innovative, smart materials is environmental
E. Molly Frazar, Anicah Smith, Thomas Dziubla, J. Zach Hilt   +3 more
doaj   +1 more source

PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering

Acta Biomaterialia, 2016
Injectable biomaterials offer a non-invasive approach to deliver cells into the myocardial infarct region to maintain a high level of cell retention and viability and initiate the regeneration process. However, previously developed injectable matrices often suffer from low bioactivity or poor mechanical properties. To address this need, we introduced a
Ali Navaei, Danh Truong, John Heffernan, Josh Cutts, David Brafman, Rachael W. Sirianni, Brent Vernon, Mehdi Nikkhah   +7 more
openaire   +2 more sources

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

Sliding Crosslinked Thermoresponsive Materials: Polypseudorotaxanes Made of Poly(N-Isopropylacrylamide) and Acrylamide-γ-Cyclodextrin

Frontiers in Chemistry, 2018
Novel polypseudorotaxanes (PPR) based on poly(N-isopropylacrylamide) (PNIPAAm) and acrylamide-γ-cyclodextrin (AγCD) are successfully synthesized. AγCD gives rise to sliding crosslinking systems and influences the thermoresponsive and swelling behavior of
Giulio Malucelli, Jvan Dore, Davide Sanna, Daniele Nuvoli, Mariella Rassu, Alberto Mariani, Valeria Alzari   +6 more
doaj   +1 more source

Influence of polyelectrolyte on the thermosensitive property of PNIPAAm-based copolymer hydrogels

Journal of Materials Science: Materials in Medicine, 2007
A new family of poly(NIPAAm-co-2-acrylamido-2-methyl-1-propanesulfonic acid) [P(NIPAAm-co-AMPSA)] hydrogels was synthesized by incorporating negative charged AMPSA to the backbone of the PNIPAAm-based hydrogel. The effect of polyelectrolyte (i.e., PAMPSA) on the thermosensitive property of PNIPAAm hydrogels was investigated.
Xian-Zheng, Zhang, Chih-Chang, Chu
openaire   +2 more sources

Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

Droplet, Volume 5, Issue 3, July 2026.
Droplet microfluidics enables precise, versatile fabrication of hydrogel particles with controlled size, composition, and structure. This review summarizes fundamental principles, engineering strategies, and emerging applications, providing a framework for advancing microfluidic hydrogel technologies.
Zhongqiao Gan, Xu Hou
wiley   +1 more source