Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
Extraction, purification, structural characterization, bioactivities, and applications of <i>Pholiota nameko</i> polysaccharide: a review. [PDF]
Sun J +7 more
europepmc +1 more source
Identifying Subcellular Structure Components in Escherichia Coli by Crosslinking and SEC‐MS
ABSTRACT Cells are comprised of a broad spectrum of structures that compartmentalize biochemical and signaling mechanisms. These structures can be comprised of many biomolecules, but especially lipids, proteins, and nucleic acids. Techniques are limited to quantify or discover new subcellular structures.
Rachel A. Victor +3 more
wiley +1 more source
Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose +4 more
wiley +1 more source
Predictors of Peripheral Neuropathy in Metabolic Disease: A Multivariable Analysis Incorporating the Toronto Clinical Scoring System and Sudomotor Assessment. [PDF]
Mocanu Chitan C +8 more
europepmc +1 more source
Phosphorus gradient yields threshold MAOC response governed by microbial and stoichiometric controls
Read the free Plain Language Summary for this article on the Journal blog. Abstract Phosphorus (P) availability is a key factor that mediates the formation of mineral‐associated organic carbon (MAOC) in soils, yet reported responses to P fertilization are often inconsistent.
Yun Liang +5 more
wiley +1 more source
Two-step bioconversion of pyridoxal 5'-phosphate from pyridoxine through cofactor regeneration and pyridoxine 5'-phosphate oxidase evolution. [PDF]
Yang X +7 more
europepmc +1 more source
Abstract The demand for analyzing images from sources such as closed‐circuit television cameras has increased significantly. Conventional analyses, including gait and soft biometrics, typically require the comparison of two video footage clips, as these methods are predicated on video‐to‐video comparisons.
Daisuke Imoto +4 more
wiley +1 more source
Alpha-ketoglutarate accelerates granulocyte-monocyte progenitor differentiation and atherosclerotic plaque inflammation via oxoglutarate receptor 1. [PDF]
Zhao J +10 more
europepmc +1 more source
Over 9 years of SMART implementation in JSWNP, patrol effort increased, particularly during periods of external funding and incentive‐based management policies, yet spatial coverage remained uneven, and CPUE declined due to shifts in patrol strategy. Strong correlations between patrol effort, wildlife observations, and threat detections highlight the ...
Abir Man Sinchuri +3 more
wiley +1 more source

