Results 41 to 50 of about 1,648 (159)

The human RBPome: From genes and proteins to human disease [PDF]

, 2015
RNA binding proteins (RBPs) play a central role in mediating post transcriptional regulation of genes. However less is understood about them and their regulatory mechanisms.
Hashemikhabir, Seyedsasan, Janga, Sarath Chandra, Neelamraju, Yaseswini   +2 more
core   +1 more source

Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis [PDF]

, 2012
BACKGROUND: There is evidence that tumours produce substances such as cytokines and microvesicular bodies bearing bioactive molecules, which support the carcinogenic process.
Bodman-Smith, M, Chanthirakumar, C, Coulton, G, Dalgleish, AG, Dennis, JL, Fowler, DW, Gravett, AM, Kaminska, E, Liu, WM   +8 more
core   +1 more source

Tissue metabolic changes drive cytokine responses to Mycobacterium tuberculosis [PDF]

, 2018
Cellular metabolism can influence host immune responses to Mycobacterium tuberculosis (Mtb). Using a systems biology approach, differential expression of 292 metabolic genes involved in glycolysis, glutathione, pyrimidine and inositol phosphate pathways ...
Joosten, LAB, Koeken, VACM, Kumar, V, Lachmandas, E, Li, Y, Matzaraki, V, Netea, MG, Notebaart, RA, Noursadeghi, M, Oosting, M, Pollara, G, Rios-Miguel, AB, van Crevel, R, van der Pasch, E   +13 more
core   +4 more sources

Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance

Molecular & Cellular Oncology, 2018
Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (
Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski, Roman J. Szczesny   +8 more
doaj   +1 more source

A Mutation in PNPT1, Encoding Mitochondrial-RNA-Import Protein PNPase, Causes Hereditary Hearing Loss [PDF]

The American Journal of Human Genetics, 2012
A subset of nuclear-encoded RNAs has to be imported into mitochondria for the proper replication and transcription of the mitochondrial genome and, hence, for proper mitochondrial function. Polynucleotide phosphorylase (PNPase or PNPT1) is one of the very few components known to be involved in this poorly characterized process in mammals.
von Ameln, Simon, Wang, Geng, Boulouiz, Redouane, Rutherford, Mark A., Smith, Geoffrey M., Li, Yun, Pogoda, Hans-Martin, Nürnberg, Gudrun, Stiller, Barbara, Volk, Alexander E., Borck, Guntram, Hong, Jason S., Goodyear, Richard J., Abidi, Omar, Nürnberg, Peter, Hofmann, Kay, Richardson, Gu Y. P., Hammerschmidt, Matthias, Moser, Tobias, Wollnik, Bernd, Koehler, Carla M., Teitell, Michael A., Barakat, Abdelhamid, Kubisch, Christian   +23 more
openaire   +3 more sources

MicroRNA expression, survival, and response to interferon in liver cancer [PDF]

, 2009
BACKGROUND: Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease.
Ambs, S, Budhu, A, Chen, Y, Croce, CM, Fan, J, Forgues, M, Ji, J, Lee, J, Lo, CM, Man, K, Meltzer, PS, Ng, IOL, Qin, LX, Roessler, S, Shi, J, Sun, HC, Tang, ZY, Wang, XW, Yu, Z   +18 more
core   +1 more source

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium [PDF]

, 2012
Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression ...
Bauersachs, Stefan, Büttner, Mathias, Meyer, Heinrich H. D., Minten, Megan, Reichenbach, Horst-Dieter, Reichenbach, Myriam, Sax, Gerhard, Spencer, Thomas E., Ulbrich, Susanne E., Winter, Gerhard, Wolf, Eckhard   +10 more
core   +1 more source

Phenotype Similarity Regression for Identifying the Genetic Determinants of Rare Diseases. [PDF]

, 2016
Rare genetic disorders, which can now be studied systematically with affordable genome sequencing, are often caused by high-penetrance rare variants.
Greene, Daniel, NIHR BioResource, Richardson, Sylvia, Turro, Ernest   +3 more
core   +3 more sources

Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity [PDF]

, 2007
BACKGROUND: Recently, several populations of postnatal stem cells, such as multipotent adult progenitor cells (MAPCs), have been described that have broader differentiation ability than classical adult stem cells.
Ulloa-Montoya, Fernando, Kidder, Benjamin L., Pauwelyn, Karen A., Chase, Lucas G., Luttun, Aernout, Crabbe, Annelies, Geraerts, Martine, Sharov, Alexei A., Piao, Yulan, Ko, Minoru S.H., Hu, Wei-Shou, Verfaillie, Catherine   +11 more
core   +2 more sources

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature

BMC Medical Genetics, 2010
Background Human height is considered highly heritable and correlated with certain disorders, such as type 2 diabetes and cancer. Despite environmental influences, genetic factors are known to play an important role in stature determination.
Frackelton Edward C, Deliard Sandra, Garris Maria L, Thomas Kelly A, Keating Brendan J, Hou Cuiping, Glessner Joseph T, Kim Cecilia E, Sleiman Patrick M, Wang Kai, Mentch Frank D, Zhang Haitao, Bradfield Jonathan P, Li Mingyao, Zhao Jianhua, Otieno F George, Chiavacci Rosetta M, Berkowitz Robert I, Hakonarson Hakon, Grant Struan FA   +19 more
doaj   +1 more source