Results 311 to 320 of about 63,722 (339)
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Nephron Experimental Nephrology, 2006
Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filter, and in glomerular pathology. During the past few years, essential progress has been made in understanding the molecular mechanisms that govern podocyte cytoskeletal dynamics, nevertheless this knowledge remains incomplete ...
Lawrence B. Holzman, Marcus J. Moeller
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Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filter, and in glomerular pathology. During the past few years, essential progress has been made in understanding the molecular mechanisms that govern podocyte cytoskeletal dynamics, nevertheless this knowledge remains incomplete ...
Lawrence B. Holzman, Marcus J. Moeller
openaire +3 more sources
The role of the podocyte in glomerulosclerosis
Current Opinion in Nephrology and Hypertension, 1999Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The 'classic' lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane.
Wilhelm Kriz, Kevin V. Lemley
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Current Medicinal Chemistry, 2008
Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, including loss of podocytes.
Markus Lassila +8 more
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Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, including loss of podocytes.
Markus Lassila +8 more
openaire +3 more sources
Journal of Cellular Physiology, 2018
Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN).
Tao Zhang +6 more
semanticscholar +1 more source
Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN).
Tao Zhang +6 more
semanticscholar +1 more source
Podocytes, glucose and insulin
Current Opinion in Nephrology and Hypertension, 2010In the last decade the importance of the podocyte in maintaining the integrity of the glomerular filtration barrier and prevention of albuminuria has become obvious. The leading cause of renal failure in the developed world is diabetic nephropathy. This has a defined natural history of progressive albuminuria.
Welsh, Gavin I, Coward, Richard J M
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Modes of podocyte death in diabetic kidney disease: an update
JN. Journal of Nephrology (Milano. 1992), 2022Anni Jiang, A. Song, Chun Zhang
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Current Opinion in Nephrology and Hypertension, 2001
Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
Karlhans Endlich +2 more
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Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
Karlhans Endlich +2 more
openaire +3 more sources
Journal of Cellular Physiology, 2019
Podocyte damage is a hallmark of diabetic nephropathy (DN). Accumulating evidence indicates that microRNAs play important roles in the DN pathogenesis. This study aimed to explore the possible roles and underlying mechanisms of miR‐15b‐5p on high glucose
Yanqin Fu +5 more
semanticscholar +1 more source
Podocyte damage is a hallmark of diabetic nephropathy (DN). Accumulating evidence indicates that microRNAs play important roles in the DN pathogenesis. This study aimed to explore the possible roles and underlying mechanisms of miR‐15b‐5p on high glucose
Yanqin Fu +5 more
semanticscholar +1 more source
The role of podocytes in proteinuria
Nephrology, 2007SUMMARY: Glomerular visceral epithelial cells, also known as podocytes, are highly specialized epithelial cells that cover the outer layer of the glomerular basement membrane. Podocytes consist of cell bodies, major processes and foot processes (FP) of neighbouring cells, with the filtration slits bridged by the slit membrane between them.
Fumiko Kodama +4 more
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Experimental Cell Research, 2012
In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet Garg +2 more
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In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet Garg +2 more
openaire +3 more sources