Results 321 to 330 of about 68,048 (352)
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The role of the podocyte in glomerulosclerosis
Current Opinion in Nephrology and Hypertension, 1999Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The 'classic' lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane.
W, Kriz, K V, Lemley
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Current Opinion in Nephrology and Hypertension, 2001
Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
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Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
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Podocytes, glucose and insulin
Current Opinion in Nephrology and Hypertension, 2010In the last decade the importance of the podocyte in maintaining the integrity of the glomerular filtration barrier and prevention of albuminuria has become obvious. The leading cause of renal failure in the developed world is diabetic nephropathy. This has a defined natural history of progressive albuminuria.
Welsh, Gavin I, Coward, Richard J M
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The role of podocytes in proteinuria
Nephrology, 2007SUMMARY: Glomerular visceral epithelial cells, also known as podocytes, are highly specialized epithelial cells that cover the outer layer of the glomerular basement membrane. Podocytes consist of cell bodies, major processes and foot processes (FP) of neighbouring cells, with the filtration slits bridged by the slit membrane between them.
Katsuhiko, Asanuma +4 more
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Experimental Cell Research, 2012
In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet, Garg, Lawrence B, Holzman
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In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of ...
Puneet, Garg, Lawrence B, Holzman
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Microscopy Research and Technique, 2002
AbstractPodocytes possess receptors for a variety of hormones. The following receptors whose stimulation results in increased cAMP levels have been detected in podocytes: adrenergic β2 receptor, dopamine D1 receptor, prostaglandin IP and EP4 receptors, and parathyroid hormone (PTH)/PTH‐related protein (PTHrP) receptor. Besides activating protein kinase
Nicole, Endlich, Karlhans, Endlich
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AbstractPodocytes possess receptors for a variety of hormones. The following receptors whose stimulation results in increased cAMP levels have been detected in podocytes: adrenergic β2 receptor, dopamine D1 receptor, prostaglandin IP and EP4 receptors, and parathyroid hormone (PTH)/PTH‐related protein (PTHrP) receptor. Besides activating protein kinase
Nicole, Endlich, Karlhans, Endlich
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Current Opinion in Nephrology and Hypertension, 2009
The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex podocyte architecture.Podocytes are composed of a ...
Simons, Matias +2 more
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The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex podocyte architecture.Podocytes are composed of a ...
Simons, Matias +2 more
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Podocyte regeneration: who can become a podocyte?
The American journal of pathology, 2013This Commentary highlights the article by Pippin et al that showed that renin lineage cells may enhance glomerular regeneration by serving as progenitors for glomerular epithelial cells in glomerular disease characterized by podocyte depletion.
Florian, Grahammer +2 more
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