Results 31 to 40 of about 499 (150)

Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy. [PDF]

open access: yesPLoS ONE, 2016
Chronic kidney disease is a major complication of Fabry disease. Podocytes accumulate globotriaosylceramide inclusions more than other kidney cell types in Fabry patients. Podocyte injury occurs early in age, and is progressive.
Brent Fall   +8 more
doaj   +1 more source

Post-partum podocyturia following pre-eclamptic pregnancy [PDF]

open access: yesPost-partum podocyturia following pre-eclamptic pregnancy
Aim: Urine podocin mRNA expression and urine podocin : nephrin mRNA expression ratio (PNR) increase with increasing proteinuria during pregnancy complicated with pre-eclampsia (PE). This suggests that urine podocytes with reduced nephrin mRNA expression are abundant in pathological podocyturia.
Umazume, Takeshi   +9 more
core   +1 more source

Peptide Charge Derivatization as a Tool for Early Detection of Preeclampsia by Mass Spectrometry—A Comparison with the ELISA Test

open access: yesMolecules, 2021
Early detection of any preeclampsia biomarkers may lower the risk of mortality, both for a mother and a child. Our study focuses on techniques for preeclampsia biomarker identification by comparing the results of a method using liquid chromatography mass
Paulina Grocholska   +8 more
doaj   +1 more source

342 Podocyturia As An Early Marker of Preeclampsia [PDF]

open access: yesAmerican Journal of Kidney Diseases, 2011
Joseph Grande   +3 more
core   +2 more sources

CMIP interacts with WT1 and targets it on the proteasome degradation pathway

open access: yesClinical and Translational Medicine, Volume 11, Issue 7, July 2021., 2021
INS patients show increased CMIP and decreased WT1 expression in podocytes. CMIP inhibits NF‐κB‐driven WT1 transcription in M15 cells. CMIP targets WT1 to proteasome degradation via ubiquitin ligase activity in M15 cells. RNAi against Cmip restores Wt1 expression in a mouse model of proteinuria.
Shao‐Yu Zhang   +8 more
wiley   +1 more source

Ethanolic Extract of Centella asiatica Treatment in the Early Stage of Hyperglycemia Condition Inhibits Glomerular Injury and Vascular Remodeling in Diabetic Rat Model

open access: yesEvidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Background. Diabetes mellitus (DM) is marked by oxidative stress, inflammation, and vascular dysfunction that caused diabetic nephropathy that resulted in end‐stage renal disease (ESRD). Vascular dysfunction is characterized by an imbalance in vasoconstrictor and vasodilator agents which underlies the mechanism of vascular injury in DM.
Wiwit A. W. Setyaningsih   +5 more
wiley   +1 more source

Urinary Nephrin: A Potential Biomarker of Early Glomerular Injury in a Cohort of Pregnant Women Attending Routine Antenatal Care Services. [PDF]

open access: yesInt J Nephrol
Introduction: Glomerular injury may occur during pregnancy as a consequence of systemic disease and pregnancy‐related medical complications. While urinary nephrin has been shown to provide early identification of preeclampsia (PE) in high‐risk pregnancies, the role of urinary nephrin in determining glomerular injury in pregnant women is yet to be ...
Mesfine BB   +5 more
europepmc   +2 more sources

Detection of Podocin in Human Urine Sediment Samples by Charge Derivatization and LC-MS-MRM Method. [PDF]

open access: yesInt J Mol Sci, 2020
Detection of podocytes in urine might serve as a useful diagnostic tool in both primary and secondary glomerular diseases. The utility of podocyturia has been confirmed for both pre-eclampsia and glomerulonephritis.
Bąchor R   +6 more
europepmc   +2 more sources

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