Results 141 to 150 of about 19,338 (290)

Decorin Evokes a Pro‐Lysosomal Pathway in Lymphatic Endothelial Cells

Proteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT The lymphatic system is critical to the body's immune and circulatory system, and lymphangiogenesis, the development of new lymphatic vessels from pre‐existing ones, is a significant process capitalized upon by cancer during tumorigenesis. Decorin is a small leucine‐rich proteoglycan which we have previously shown to be anti‐tumorigenic and a ...
Gabriel J. Pascal, Dipon K. Mondal, Sadie Kim, Christopher Xie, Devanarayanan Siva Sankar, Jörn Dengjel, Renato V. Iozzo   +6 more
wiley   +1 more source

Prognostic significance of lymphangiogenesis in pharyngolaryngeal carcinoma patients [PDF]

, 2011
Background: Lymphatic vessel spread is considered a major route for head and neck squamous cell carcinoma metastasis. Formation of new lymphatic vessels could facilitate the process, raising the malignant potential of these tumours. Recent identification
Astudillo, Aurora, García-Carracedo, Darío, González, M.V. (María), Rodrigo, J.P. (Juan), Suarez, Carlos   +4 more
core  

Peripheral ameloblastoma of the upper gingiva: Report of a case and literature review [PDF]

, 2014
According to the 2005 histological classification of odontogenic neoplasms by the World Health Organization, ameloblastoma is a benign, locally invasive epithelial odontogenic tumor of putative enamel organ origin.
Albanese, Massimo, Bertossi, Dario, De Florio, Iride, De Santis, Daniele, Favero, Vittorio, Lo Muzio, L., Martano, Manuela, Nocini, Pier Francesco, Padovano di Leva, Antongiulio   +8 more
core   +1 more source

Calumenin, A Calcium‐Binding Modulatory Protein, Effective in Pathological Calcifications and Cancers, With Therapeutic Application Promise

FASEB BioAdvances, Volume 7, Issue 10, October 2025.
Calumenin (CALU) is effective in calcium homeostasis, involved in various cellular processes, ER‐related functions, normal calcification processes, pathological calcium deposits, inflammatory diseases, and cancers. Additionally, it has been linked to cancer by controlling the γ‐carboxylation of vitamin K‐dependent proteins linked to cancer.
Parinaz Nasri Nasrabadi, Babak Jahangiri, Zahra Amiri, Forouzandeh Mahjoubi, Fatemeh Masoumi, Alireza Zomorodipour   +5 more
wiley   +1 more source

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers

Immunological Reviews, Volume 335, Issue 1, October 2025.
ABSTRACT Tertiary lymphoid structures (TLSs) arise in non‐lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and beyond, TLSs range from loose aggregates of immune cells to fully mature structures containing functional germinal centers (GC).
Stephane M. Guillaume, Cristian G. Beccaria, Matteo Iannacone, Michelle A. Linterman   +3 more
wiley   +1 more source

An Examination of Sirolimus's Role in Endothelial Cells of Kaposiform Haemangioendothelioma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Kaposiform haemangioendothelioma (KHE) research faces challenges due to the lack of established cell lines and suitable animal models. Our study aimed to establish KHE cell lines, spheroids and refine murine models to mimic disease characteristics, advancing our understanding of KHE pathogenesis and exploring novel therapies. Primary KHE cells
Yanan Li, Chuan Wang, Meng Kong, Li Li, Yi Ji   +4 more
wiley   +1 more source

Comparing Immunohistochemical Expression of Podoplanin between Oral Squamous Cell Carcinoma and Normal Oral Mucosa

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. Podoplanin is a mucin-like integral membrane glycoprotein that is expressed in the lymphatic endothelial cells but not in the blood vascular ...
Samareh Jazayeri, Maryam Seyedmajidi, Fatima Bijani, Seyedali Seyedmajidi   +3 more
doaj  

The role of lymphatics in renal inflammation [PDF]

, 2017
Progressive renal diseases are characterized by tubulointerstitial inflammatory cell recruitment, tubular atrophy and fibrosis. Various aspects of the recruitment of leukocytes have been extensively studied, but the exit routes (i.e.
Bonani, Marco, Seeger, Harald, Segerer, Stephan   +2 more
core  

Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation [PDF]

, 2012
Osteocytes are terminally differentiated osteoblasts which reside in a mineralized extracellular matrix (ECM). The factors that regulate this differentiation process are unknown.
Farquharson, C., Loveridge, N., Pitsillides, A. A., Prideaux, M.   +3 more
core   +3 more sources

Expression of Heart Development Protein With EGF‐Like Domains 1 (HEG1) Decorated With Low‐Sulfated Keratan Sulfate in Human Malignant Pleural Mesothelioma

Pathology International, Volume 75, Issue 10, Page 504-512, October 2025.
The purpose of this study is to investigate sulfation modification of the glycan structure decorating HEG1, one of the diagnostic markers of malignant pleural mesothelioma (MPM), in MPM. Immunohistochemical analysis reveals low‐sulfated keratan sulfate (KS) expression, recognized by 294‐1B1 and R‐10G, in MPM tissues with HEG1 expression.
Koki Nakashima, Hitomi Hoshino, Zui Zhang, Tomoya O. Akama, Nobuyuki Kondo, Seiki Hasegawa, Yoshitaka Sekido, Mana Fukushima, Tamotsu Ishizuka, Motohiro Kobayashi   +9 more
wiley   +1 more source