Results 221 to 230 of about 13,097 (241)

Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2016
Podoplanin (PDPN) is a type-I transmembrane sialoglycoprotein, which possesses a platelet aggregation-stimulating (PLAG) domain in its N-terminus. Among the three PLAG domains, O-glycan on Thr52 of PLAG3 is critical for the binding with C-type lectin-like receptor-2 (CLEC-2) and is essential for platelet-aggregating activity of PDPN. Although many anti-
Yukinari, Kato, Satoshi, Ogasawara, Hiroharu, Oki, Ryusuke, Honma, Michiaki, Takagi, Yuki, Fujii, Takuro, Nakamura, Noriko, Saidoh, Hazuki, Kanno, Mitsuo, Umetsu, Satoshi, Kamata, Hiroshi, Kubo, Mitsuhiro, Yamada, Yoshihiko, Sawa, Kei-Ichi, Morita, Hiroyuki, Harada, Hiroyoshi, Suzuki, Mika Kato, Kaneko   +17 more
openaire   +2 more sources

Podoplanin expression in oral leukoplakia: Tumorigenic role

Oral Oncology, 2013
Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelial dysplasia.In this retrospective study ...
Juan Carlos, de Vicente, Juan Pablo, Rodrigo, Tania, Rodriguez-Santamarta, Paloma, Lequerica-Fernández, Eva, Allonca, Juana María, García-Pedrero   +5 more
openaire   +2 more sources

PMab-44 Detects Bovine Podoplanin in Immunohistochemistry

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2016
Podoplanin (PDPN)/Aggrus is a type I transmembrane O -glycoprotein, which is expressed in several normal tissues including podocytes of kidney and lymphatic endothelial cells. PDPN activates platelet aggregation by binding to C-type lectin-like receptor-2 (CLEC-2) on platelet; however, only ...
Ryusuke, Honma, Satoshi, Ogasawara, Mika K, Kaneko, Yuki, Fujii, Hiroharu, Oki, Takuro, Nakamura, Michiaki, Takagi, Satoru, Konnai, Yukinari, Kato   +8 more
openaire   +2 more sources

Podoplanin: A Novel Diagnostic Immunohistochemical Marker

Advances in Anatomic Pathology, 2006
Podoplanin is a transmembrane mucoprotein recognized by the recently commercially available D2-40 monoclonal antibody. Recent investigations have shown that podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Podoplanin has also
openaire   +2 more sources

Cancer-associated fibroblasts promote venous thrombosis through podoplanin/CLEC-2 interaction in podoplanin-negative lung cancer mouse model.

Journal of Thrombosis and Haemostasis, 2023
Toshiaki Shirai, N. Tsukiji, Tomoyuki Sasaki, Saori Oishi, Ryohei Yokomori, Katsuhiro Takano, K. Suzuki-Inoue   +6 more
semanticscholar   +1 more source

Characterization of Anti-podoplanin Monoclonal Antibodies: Critical Epitopes for Neutralizing the Interaction Between Podoplanin and CLEC-2

Hybridoma, 2008
Podoplanin (Aggrus) is a mucin-type sialoglycoprotein that is known as a useful marker for lymphatic endothelium and tumor-initiating cells (TICs). Interaction between podoplanin and C-type lectin-like receptor-2 (CLEC-2) is reported to be critical for podoplanin-induced platelet aggregation and cancer metastasis.
Satoshi, Ogasawara, Mika Kato, Kaneko, Janet E, Price, Yukinari, Kato   +3 more
openaire   +2 more sources

PMab-210: A Monoclonal Antibody Against Pig Podoplanin

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2019
Podoplanin (PDPN) is a type I transmembrane glycoprotein that is expressed in normal tissues, including renal corpuscles and type I lung alveolar cells. Monoclonal antibodies (mAbs) against human, mouse, rat, rabbit, dog, cat, and bovine PDPNs have already been established; however, antipig PDPN (pPDPN) mAbs have not.
Yoshikazu, Furusawa, Shinji, Yamada, Shunsuke, Itai, Masato, Sano, Takuro, Nakamura, Miyuki, Yanaka, Masato, Fukui, Hiroyuki, Harada, Takuya, Mizuno, Yusuke, Sakai, Masaki, Takasu, Mika K, Kaneko, Yukinari, Kato   +12 more
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Blocking podoplanin inhibits platelet activation and decreases cancer-associated venous thrombosis.

Thrombosis Research, 2021
Xia Wang, Biao Liu, Mengqiao Xu, Yi-xiu Jiang, Jundong Zhou, Jun Yang, Haidi Gu, C. Ruan, Jinchang Wu, Yiming Zhao   +9 more
semanticscholar   +1 more source

Podoplanin

2008
Andreas Wicki, Gerhard Christofori
openaire   +1 more source

Podoplanin expression in cancer-associated fibroblasts predicts unfavorable prognosis in node-negative breast cancer patients with hormone receptor-positive/HER2 − negative subtype

Breast Cancer, 2021
Yuko Tanaka, T. Ohno, T. Kadonaga, Yoshiteru Kidokoro, M. Wakahara, K. Nosaka, Tomohiko Sakabe, Yoshimasa Suzuki, Hiroshige Nakamura, Y. Umekita   +9 more
semanticscholar   +1 more source