First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, Volume 13, Issue 32, 9 June 2026.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
Premature ovarian insufficiency in patients with systemic lupus erythematosus on cyclophosphamide: a systematic review and meta-analysis. [PDF]
Front Endocrinol (Lausanne)García-Sáenz MR +12 more
europepmc +1 more source
Are seizure forecasts and cycles better than chance? What chance?
Epilepsia, Volume 67, Issue 6, Page 2966-2978, June 2026.Abstract Objective There is a growing synergy between the lines of research on cycles in epilepsy and seizure forecasting. It has been conjectured, for instance, that incorporating information about significant seizure cycles into forecasting algorithms can lead to a better‐than‐chance forecasting performance.
Ralph G. Andrzejak +4 more
wiley +1 more source
Establishment of an Autoimmune Premature Ovarian Insufficiency Mouse Model with Proteomic Analyses: An Exploratory Study. [PDF]
Int J Mol SciTian Y, Zhou J, Pei X, Liu F, Diao F.
europepmc +1 more source
Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, Volume 3, Issue 2, Page 237-251, June 2026.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source
Forensic trace DNA analysis to answer activity-level questions in a realistic-scenario activity study based upon the case of Idaho v Bryan C. Kohberger. [PDF]
Forensic Sci Int SynergAlviar A, Wickenheiser R, Hall A.
europepmc +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.A high‐fat, high‐sugar (HFHS) diet induces premature ovarian insufficiency (POI), characterized by reduced follicular reserve, increased atresia, fibrosis, and excessive granulosa cell autophagy. Electroacupuncture (EA) at CV4, ST36, and SP6 suppresses METTL3 expression and reduces m6A methylation of Beclin1 mRNA, thereby limiting Beclin1 translation ...
Lele Ling +9 more
wiley +1 more source
The role of hormonal markers in predicting reproductive lifespan in girls with Turner syndrome-a retrospective study. [PDF]
J Endocr Socvan der Coelen S +7 more
europepmc +1 more source
Hydrographic structure in the Ulleung Basin in September 2006
, 2006 Korea Ocean Research and Development Institute conducted a hydrographic survey in the Ulleung Basin in the East Sea in September 2006. A small warm eddy characterized by homogeneous 10℃ water appeared in 100 - 200 m depths in the region southwest of ...
민홍식 +4 more
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