Results 51 to 60 of about 1,557 (194)

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Privacy-enhanced personalized POI recommendation with federated learning framework

Complex & Intelligent Systems
With the development of O2O e-commerce, POI recommendation services are increasingly important in integrating online and offline consumer scenarios.
Chunhua Ju, Zhaohui Wang, Chonghuan Xu, Fuguang Bao   +3 more
doaj   +1 more source

Menopause and comorbidity assessment in cisgender women living with HIV in Victoria: A clinic record review of women seen at three tertiary centres in Melbourne, Australia

HIV Medicine, EarlyView.
Abstract Background Data on women ageing with HIV in Australia are limited, particularly regarding those in midlife and experiencing menopause. The aim of this study is to describe the demographic characteristics of cisgender women living with HIV who attend the Alfred Hospital, Monash Medical Centre and Melbourne Sexual Health Centre for primary HIV ...
Anna B. Pierce, Sushena Krishnaswamy, Philip Rawson‐Harris, Wajeeha Fatima, Melanie Bissessor, Jennifer F. Hoy   +5 more
wiley   +1 more source

The Random Power Function for Tests Based on Pivotal Quantities

International Statistical Review, EarlyView.
Summary In clinical trials planning, evaluation of the probability of success of an experiment is of central interest, for instance, in sample size determination. This assessment typically involves analyses of the power function of a test on a parameter of interest, such as a relevant treatment effect.
Fulvio De Santis, Stefania Gubbiotti, Francesco Mariani   +2 more
wiley   +1 more source

Where To Go at the Next Timestamp

Data Science and Engineering
The next Point of Interest (POI) recommendation is the core technology of smart city. Current state-of-the-art models attempt to improve the accuracy of the next POI recommendation by incorporating temporal and spatial intervals or by partitioning the ...
Jiaqi Duan, Xiangfu Meng, Guihong Liu
doaj   +1 more source

Carotid artery dissection linked to intermittent apnoeic swimming: A case–control study

Experimental Physiology, EarlyView.
Abstract Internal carotid artery (ICA) dissection is a rare and potentially devastating cause of cerebral ischaemia, initiated by an intimal tear or rupture of the vasa vasorum, that can lead to an intraluminal thrombus, vascular stenosis, occlusion, or dissecting aneurysm formation.
Damian M. Bailey, Richard G. Davies, Brenig L. Gwilym, Benjamin S. Stacey, Danny Walmsley, Michael H. Lewis, Josip Butkovic, Ivan Mumlek, Brad Perry, Zvonomir Vrselja, Shigehiko Ogoh, James A. Pawelczyk, Mohamad Bashir, Richard D. White, Ian M. Williams   +14 more
wiley   +1 more source

Assessing Household Welfare in Response to Rising Food Prices in The Gambia

Applied Economic Perspectives and Policy, Volume 48, Issue 4, Page 1167-1184, September 2026.
ABSTRACT This study examines how rising food prices affected household welfare in The Gambia using nationally representative data from the 2015/16 Integrated Household Survey (IHS‐3). The analysis reflects household consumption behavior and market conditions prevailing during that period and provides a structural benchmark for understanding ...
Roger Vorsah, Obed Quaicoe, Fafanyo Asiseh, John N. Ng'ombe   +3 more
wiley   +1 more source

A Privacy-Preserving Framework for Trust-Oriented Point-of-Interest Recommendation

IEEE Access, 2018
Point-of-interest (POI) recommendation has attracted many interests recently because of its significant potential for helping users to explore new places and helping location-based service (LBS) providers to carry out precision marketing.
An Liu, Weiqi Wang, Zhixu Li, Guanfeng Liu, Qing Li, Xiaofang Zhou, Xiangliang Zhang   +6 more
doaj   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source