Results 101 to 110 of about 2,342,845 (294)

Review of Health Economics of Point-of-Care Testing Worldwide and Its Efficacy of Implementation in the Primary Health Care Setting in Remote Australia

Risk Management and Healthcare Policy, 2020
Hoi Yan Wong,1 Loredana G Marcu,2,3 Eva Bezak,1,3,4 Nayana Anupam Parange1,3 1Division of Health Sciences, University of South Australia, Adelaide, SA 5000, Australia; 2Faculty of Informatics & Science, University of Oradea, Oradea 410087, Romania ...
Wong HY, Marcu LG, Bezak E, Parange NA
doaj  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The cost-effectiveness of upfront point-of-care testing in the emergency department: a secondary analysis of a randomised, controlled trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019
Background Time-saving is constantly sought after in the Emergency Department (ED), and Point-of-Care (POC) testing has been shown to be an effective time-saving intervention.
Lara Nicole Goldstein, Mike Wells, Craig Vincent-Lambert   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Tracking the progress of HIV: the impact of point-of-care tests on antiretroviral therapy

Clinical Epidemiology, 2013
Steven D Reid, Sarah J Fidler, Graham S Cooke Department of Infectious Diseases, St Mary's Hospital, Imperial College London, London, UK Abstract: It is now around 30 years since the discovery of HIV, the virus that causes AIDS.
Reid SD, Fidler SJ, Cooke GS
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Assessment of the diagnostic performance of TrueHb® point-of-care hemometer compared with Sysmex i3 analyzer among patients at International Hospital Kampala, Uganda

Journal of Blood Medicine, 2019
Ivan Mugisha Taremwa,1 Ivan Ndeze,1 Bashir Mwambi,1 Christine Atuhairwe,2 Diana Inda Achieng,3 Bernard Natukunda41Department of Medical Laboratory Sciences, Institute of Allied Health Sciences, Clarke International University, Kampala, Uganda; 2Institute
Taremwa IM, Ndeze I, Mwambi B, Atuhairwe C, Achieng DI, Natukunda B   +5 more
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Factors determining patients' intentions to use point-of-care testing medical devices for self-monitoring: the case of international normalized ratio self-testing

Patient Preference and Adherence, 2012
Syed Ghulam Sarwar Shah,1 Julie Barnett,1 Jasna Kuljis,2 Kate Hone,2 Richard Kaczmarski31Multidisciplinary Assessment of Technology Centre for Healthcare, 2Department of Information Systems and Computing, Brunel University London, Uxbridge, Middlesex, UK;
Shah SG, Barnett J, Kuljis J, Hone K, Kaczmarski R   +4 more
doaj  

Choosing wisely: Improving decision-making for deployment of diagnostics in primary care settings

Journal of Family Medicine and Primary Care
Background: Despite the availability of WHO and ICMR’s list of essential diagnostics, there is limited guidance to primary care providers on choosing and deploying the most appropriate diagnostics. Objectives: The study aimed to identify diagnostic tests
Varsha Shridhar, Vasudha Kannan, Ramakrishna Prasad, Pavitra Mohan   +3 more
doaj   +1 more source