Results 131 to 140 of about 168,762,675 (301)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Randomized comparison of in vivo performance of two point-of-care tear film osmometers
Clinical Ophthalmology, 2017 Jerry Nolfi, Barbara Caffery Toronto Eye Care Optometric Clinic, Toronto, ON, Canada Purpose: To compare the in vivo precision of two commercially available point-of-care osmometers among normal subjects with no dry eye disease. Methods: Twenty healthy
Nolfi J, Caffery B
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Role Of Point Of Care Ultrasound In The Diagnosis Of Retinal Detachment In The Emergency Department
Open Access Emergency Medicine, 2019 Shadi Lahham,1 Qumber Ali,2 Bea Martina Palileo,3 Clifton Lee,3 John C Fox1 1University of California, Irvine, Department of Emergency Medicine, Orange, CA 92868, USA; 2Touro University, School of Medicine, Henderson, NV 89014, USA; 3University of ...
Lahham S +4 more
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Other title: About the Kansas Health Care Provider Insurance Availability Act
, 2018 application/pdf; August 2018. Date taken from Kansas Health Care Stabilization Fund website."The original Health Care Provider Insurance Availability Act was enacted in 1976 at a time when many physicians and other health care providers could not obtain ...
Kansas. Board of Governors of the Health Care Stabilization Fund.
core +1 more source
Facing Unmet Needs in Medicine Access at the Point of Care
Medicine Access @ Point of Care, 2017 Giulio Zuanetti
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source