Results 131 to 140 of about 2,236,063 (306)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protocol for the creation and characterization of SARS-CoV-2 variant testing panels using remnant clinical samples for diagnostic assay testing

STAR Protocols
Summary: The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Alpha variant in 2020 demonstrated the need for reanalysis of diagnostic tests to ensure detection of emerging variants.
Leda Bassit, Heather B. Bowers, Morgan Greenleaf, Courtney Sabino, Eric Lai, Grace Yu, Anne Piantadosi, Ethan Wang, William O’Sick, Kaleb McLendon, Julie A. Sullivan, Raymond F. Schinazi, Gregory L. Damhorst, Wilbur Lam, Anuradha Rao   +14 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Point-of-Care [PDF]

Choonpa Igaku, 2020
openaire   +2 more sources

Toward diagnostic preparedness: detection of highly pathogenic avian influenza A(H5N1) in contrived nasal swab specimens using rapid antigen and point-of-care molecular tests

Journal of Clinical Microbiology
Highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b was first detected in birds in 2021 in the United States (U.S.). An ongoing outbreak in dairy cattle began in early 2024 involving genotype B3.13. At least 70 U.S. cases have been identified
Leda Bassit, Gregory L. Damhorst, Heather B. Bowers, Courtney Sabino, Julie Sullivan, Emily B. Kennedy, Jacob Khouri, Pamela Miller, Eric Lai, Raymond F. Schinazi, Wilbur A. Lam, Nira R. Pollock, Anuradha Rao   +12 more
doaj   +1 more source

Lensfree computational microscopy tools for cell and tissue imaging at the point-of-care and in low-resource settings. [PDF]

, 2012
The recent revolution in digital technologies and information processing methods present important opportunities to transform the way optical imaging is performed, particularly toward improving the throughput of microscopes while at the same time ...
Bishara, Waheb, Greenbaum, Alon, Isikman, Serhan O, Lee, Myungjun, Mudanyali, Onur, Ozcan, Aydogan, Su, Ting-Wei   +6 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Diagnostic Performance of Point-of-Care Troponin I and Laboratory Troponin T in Patients Presenting to the ED with Chest Pain: A Comparative Study

Open Access Emergency Medicine, 2020
Osama H Mohammad,1 Vamanjore A Naushad,1 Nishan K Purayil,1 Laith Sinan,2 Naseem Ambra,1 Prem Chandra,3 Firjeeth C Paramba,1 Jassim Mohammad,4 Sajid Chalihadan,1 Irfan Varikkodan,1 Azeez Palol1 1Department of General Internal Medicine, Hamad Medical ...
Mohammad OH, Naushad VA, Purayil NK, Sinan L, Ambra N, Chandra P, Paramba FC, Mohammad J, Chalihadan S, Varikkodan I, Palol A   +10 more
doaj  

Point-of-care ultrasonography for anesthesiologists☆

Colombian Journal of Anesthesiology, 2015
La ecografia hecha por el clinico (POCUS por su sigla en ingles: point-of-care ultrasound) se realiza e interpreta al lado de la cama del paciente. De esa forma se obtienen hallazgos en tiempo real, es posible establecer la correlacion clinica con los signos y sintomas, y ademas se pueden repetir las imagenes dinamicas en caso de cambios en la ...
openaire   +1 more source