Results 161 to 170 of about 2,291,402 (391)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

The interplay between the tumor microenvironment and tumor-derived small extracellular vesicles in cancer development and therapeutic response

Cancer Biology & Therapy
The tumor microenvironment (TME) plays an essential role in tumor cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment.
Xuanyu Guo, Jiajun Song, Miao Liu, Xinyi Ou, Yongcan Guo   +4 more
doaj   +1 more source

The Use of Point-of-Care Ultrasound for Arthrocentesis Among Emergency Medicine Residents

Open Access Emergency Medicine, 2021
Josie Acuna, Adrienne Yarnish, Elaine Situ-LaCasse, Richard Amini, Srikar Adhikari Department of Emergency Medicine, University of Arizona, Tucson, AZ, USACorrespondence: Josie AcunaDepartment of Emergency Medicine, The University of Arizona Medical ...
Acuna J, Yarnish A, Situ-LaCasse E, Amini R, Adhikari S   +4 more
doaj  

Point of care testing improves process but not outcome in patients in A and E [PDF]

, 1998

openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Choosing wisely: Improving decision-making for deployment of diagnostics in primary care settings

Journal of Family Medicine and Primary Care
Background: Despite the availability of WHO and ICMR’s list of essential diagnostics, there is limited guidance to primary care providers on choosing and deploying the most appropriate diagnostics. Objectives: The study aimed to identify diagnostic tests
Varsha Shridhar, Vasudha Kannan, Ramakrishna Prasad, Pavitra Mohan   +3 more
doaj   +1 more source

Point-of-Care Testing: Teamwork and Collaboration Initiate Health Care Change [PDF]

, 1997
Vicki Kendrick, Mary Cavin, Kathryn Vorster   +2 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Point of care tests for hospital-acquired infections (HAIs) : economic analysis report [PDF]

A number of clinical/disease areas have been prioritised by the Technology Strategy Board (TSB) and Department of Health (DH) for the DIIA Innovation Platform.
Osipenko, Leeza, Szczepura, Ala
core  

Point-of-Care Testing of Triglycerides: Evaluation of the Accutrend Triglycerides System [PDF]

, 2000
Claus Luley, Gunnar Ronquist, W Reuter, Valerie Paal, Hans-Detlev Gottschling, Sabine Westphal, George L. King, Stephan J. L. Bakker, Robert J. Heine, Andrew Hattemer   +9 more
openalex   +1 more source