Results 141 to 150 of about 6,659,408 (317)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Summary of Research 1996, Department of Systems Management [PDF]
, 1996 The views expressed in this report are those of the authors and do not reflect the official policy or position of the Department of Defense or the U.S.
Faculty of the Department of Systems Management, Naval Postgraduate School
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Saudi Journal of AnaesthesiaCongenital complete atrioventricular block (CCAVB) is a rare but high-risk condition with significant maternal and fetal morbidity and mortality. Management often involves pacemaker implantation, yet anesthetic guidelines for pregnant women with CCAVB ...
João Tiago Silva +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
City of Myrtle Point bicycle and pedestrian plan
, 1995 217 pp. Includes maps and figures. Published May 1995. Received from ODOT January 2, 2007.The City's Pedestrian and Bicycle Plan coordinates with state and federal plans. It describes a system that can be implemented over 20 years.
Myrtle Point (Or.) +1 more
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The organisation of formal long-term care for the elderly. Results from the 21 European country studies in the ANCIEN project. ENEPRI Research Report No. 95, November 2011 [PDF]
, 2011 This report investigates the organisation and provision of long-term care for the elderly population in 21 member states of the European Union, thus including both old as well as new member states.
Kraus, Markus, Riedel, Monika
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First Clinical Description of Coagulation of Whole Blood with Resonant Acoustic Rheometry
DiagnosticsBackground/Objectives: The timely evaluation of blood clot formation and breakdown is essential in the care of patients with severe bleeding or critical illness.
Connor M. Bunch +16 more
doaj +1 more source
Automated integration of wireless biosignal collection devices for patient-centred decision-making in point-of-care systems. [PDF]
Healthc Technol Lett, 2016 Menychtas A, Tsanakas P, Maglogiannis I.
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source