Results 221 to 230 of about 3,175,966 (336)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Utilizing connectivity and data management system for effective quality management and regulatory compliance in point of care testing

, 2020
Angela W.S. Fung
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Criteria for designing integrated diagnosis interventions in low resource settings at the primary care level: a Delphi consensus study. [PDF]

BMC Health Serv Res
Gwaza GP, Plüddemann A, MacBain McCall M, Dittrich S, Heneghan C.   +4 more
europepmc   +1 more source

Point-of-care testing system for digital single cell detection of MRSA directly from nasal swabs

, 2020
Martin Schulz, Silvia Calabrese, Florian Hausladen, Holger Wurm, Dominik Drossart, Karl Stock, Anna M. Sobieraj, Fritz Eichenseher, Martin J. Loessner, Mathias Schmelcher, Anja Gerhardts, Ulrike Goetz, Marina Handel, Annerose Serr, Georg Haecker, Jia Li, Mara Specht, Philip Koch, M. Cobas Meyer, Philipp Tepper, Raimund Rother, Michael Jehle, Simon Wadle, Roland Zengerle, Felix von Stetten, Nils Paust, Nadine Borst   +26 more
openalex   +2 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Identification of digital clinical decision support systems for supporting diagnosis and triage of patients with shoulder disorders: A scoping review protocol. [PDF]

PLoS One
Schamerhorn CR, Peñas NM, Fletcher JR, Hayman R, Eubank BHF.   +4 more
europepmc   +1 more source

Molecular Point-of-care Testing for Influenza A/B and Respiratory Syncytial Virus: Workflow Parameters for the ID Now™ and cobas® Liat® Systems

, 2020
S. Young, Jamie E. Phillips, Christen Griego-Fullbright, Ariella Wagner, Patricia Jim, Sheetal Chaudhuri, Sitong Tang, Joanna Sickler   +7 more
openalex   +1 more source

Miniaturized Real-Time PCR systems for SARS-CoV-2 detection at the Point-of-Care

, 2022
Valeria Garzarelli, Maria Serena Chiriacò, Marco Cereda, Isidora Autuori, Francesco Ferrara   +4 more
openalex   +2 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source